Venkatakrishnan et al., J Biol Chem 2000
(Ovarian Neoplasms) :
Chemokine receptors CXCR-1/2 activate mitogen activated protein kinase via the epidermal growth factor receptor in ovarian cancer cells
Lei et al., Cardiovasc Res 2002
:
OxLDL upregulates CXCR2 expression in monocytes via scavenger receptors and activation of p38 mitogen activated protein kinase ... Furthermore, p38 MAPK inhibitors SB203580 or SK & F86002 markedly reduced oxLDL induced CXCR2 expression
van den Blink et al., J Clin Immunol 2004
(Endotoxemia) :
To investigate the role of p38 mitogen activated protein kinase ( MAPK ) in the regulation of CXCR expression during an inflammatory response in vivo, 24 healthy volunteers received an intravenous injection with lipopolysaccharide (LPS) preceded ( -3 hr ) by a specific p38 MAPK inhibitor ( BIRB 796 BS ) at a high dose ( 600 mg ) or a low dose ( 50 mg ) or a placebo