Gene interactions and pathways from curated databases and text-mining

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CXCR4 — IL13

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Bailer et al., Eur J Immunol 2000 : A quantitative flow cytometric assay revealed that IL-13 induced a significant ( approximately 50 % ) reduction in the number of CD4 and CC chemokine receptor 5 (CCR5) antibody binding sites while completely abrogating surface expression of CXC chemokine receptor 4 (CXCR4)
Creery et al., Viral Immunol 2006 : Differential regulation of CXCR4 and CCR5 expression by interleukin (IL)-4 and IL-13 is associated with inhibition of chemotaxis and human immunodeficiency Virus ( HIV ) type 1 replication but not HIV entry into human monocytes ... In this study, we investigated the effects of IL-4 and IL-13 on the expression of CXCR4 and CCR5, and the biological implications of alteration of CXCR4 and CCR5 regulation on monocytic cells with respect to their migration in response to chemokines, HIV entry, and its replication ... Although IL-13 inhibited the expression of both CXCR4 and CCR5, this downregulation of chemokine receptor expression was not sufficient to prevent virus entry