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CXCR4 — IL13
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Bailer et al., Eur J Immunol 2000
:
A quantitative flow cytometric assay revealed that
IL-13 induced a significant ( approximately 50 % ) reduction in the number of CD4 and CC chemokine receptor 5 (CCR5) antibody binding sites while completely abrogating surface expression of
CXC chemokine receptor 4 (CXCR4)
Creery et al., Viral Immunol 2006
:
Differential
regulation of
CXCR4 and CCR5 expression by interleukin (IL)-4 and
IL-13 is associated with inhibition of chemotaxis and human immunodeficiency Virus ( HIV ) type 1 replication but not HIV entry into human monocytes ... In this study, we investigated the
effects of IL-4 and
IL-13 on the expression of
CXCR4 and CCR5, and the biological implications of alteration of CXCR4 and CCR5 regulation on monocytic cells with respect to their migration in response to chemokines, HIV entry, and its replication ... Although
IL-13 inhibited the expression of both
CXCR4 and CCR5, this downregulation of chemokine receptor expression was not sufficient to prevent virus entry