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DAPK3 — TSC2

Text-mined interactions from Literome

Stevens et al., J Biol Chem 2009 : Transfection of DAPK promotes phosphorylation of TSC2 in vivo, whereas short interfering RNA mediated attenuation of DAPK reduces growth factor stimulated phosphorylation of TSC2
Lin et al., FEBS J 2011 : Furthermore, altering mTORC1 activity does not affect DAPK levels, excluding indirect effects of TSC2 on DAPK protein levels through changes in mTORC1 translational control ... Importantly, using a GTPase activating protein-dead missense mutation of TSC2, we demonstrate that the effect of TSC2 on DAPK is independent of GTPase activating protein activity ... Finally, we show that DAPK is regulated by the lysosome pathway and that lysosome inhibition blocks TSC2 mediated degradation of DAPK