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CDC42 — DOCK6

Pathways - manually collected, often from reviews:

• NCI Pathway Database Regulation of CDC42 activity: CDC42/GDP complex (CDC42) → DOCK6 (DOCK6) (modification, collaborate) Miyamoto et al., Exp Cell Res 2007
  Evidence: mutant phenotype, assay
• Reactome Reaction: DOCK6 → CDC42 (reaction) Brugnera et al., Nat Cell Biol 2002, Meller et al., J Biol Chem 2004, Nishikimi et al., FEBS Lett 2005, Hiramoto et al., Exp Cell Res 2006*, Miyamoto et al., Exp Cell Res 2007
• Reactome Reaction: DOCK6 → CDC42 (direct_complex) Brugnera et al., Nat Cell Biol 2002, Meller et al., J Biol Chem 2004, Nishikimi et al., FEBS Lett 2005, Hiramoto et al., Exp Cell Res 2006*, Miyamoto et al., Exp Cell Res 2007

Text-mined interactions from Literome

Kulkarni et al., J Biol Chem 2011 : Multiple factors confer specific Cdc42 and Rac protein activation by dedicator of cytokinesis ( DOCK ) nucleotide exchange factors ... DOCK ( dedicator of cytokinesis ) guanine nucleotide exchange factors ( GEFs ) activate the Rho-family GTPases Rac and Cdc42 to control cell migration, morphogenesis, and phagocytosis
Harada et al., Blood 2012 : Therefore, DOCK8 regulates interstitial DC migration by controlling Cdc42 activity spatially