Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Negishi et al., Neurosci Lett 2003 : In hippocampal neurons, E2 and BPA significantly inhibited the staurosporine induced increase in caspase-3 activity ... In cortical neurons, BPA and NP significantly inhibited the increase in caspase-3 activity, while E2 did not ... Furthermore, low-dose BPA ( 10 nM ) also significantly inhibited the increase in caspase-3 activity in both hippocampal and cortical neurons
Terasaka et al., Anticancer Res 2005 (Carcinoma, Squamous Cell...) : BPA activated caspase-9 and caspase-3, suggesting induction of apoptosis via caspase activation by the caspase recruitment domain
Bontempo et al., Journal of translational medicine 2009 (Leukemia, Myeloid, Acute) : BPA mediated apoptosis was caspase dependent and occurred by activation of extrinsic and intrinsic cell death pathways modulating both FAS and TRAIL and by inducing BAD phosphorylation in NB4 cells