Gene interactions and pathways from curated databases and text-mining

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DUSP16 — MAPK8

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: MAPK8 → DUSP16 (directlyDecreases, DUSP16 Activity, MAPK8 Activity)
    Evidence: DUSP8, DUSP10 and DUSP16 make up the third subgroup as they preferentially recognize JNK, p38 or both, respectively
  • KEGG MAPK signaling pathway: DUSP1/DUSP10/DUSP14/DUSP16/DUSP2/DUSP22/DUSP3/DUSP4/DUSP5/DUSP6/DUSP7/DUSP8/DUSP9 → MAPK10/MAPK8/MAPK9 (protein-protein, inhibition)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Givant-Horwitz et al., Gynecol Oncol 2004 (MAP Kinase Signaling System...) : The objective of the present study was to investigate the expression and clinical role of dual-specificity phosphatases ( DUSP ) , inhibitors of MAPK signaling, in ovarian cancer cells at this site
Kumabe et al., Microbiol Immunol 2010 : Activation of MAPK is negatively regulated by DUSP , which dephosphorylate the phosphothreonine and phosphotyrosine residues