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ECM1 — VEGFA
Text-mined interactions from Literome
Xu et al., American journal of physiology. Renal physiology 2006
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Our data also indicate that simvastatin, via mevalonate depletion, reverses
VEGF induced
ECM accumulation by preventing RhoA activation
Wang et al., Arterioscler Thromb Vasc Biol 2009
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Depletion of GIT1 by siRNA also significantly inhibited
VEGF induced MMP2 activation and
extracellular matrix ( ECM ) degradation ... Therefore, GIT1 mediates
VEGF induced matrix metalloproteinase ( MMP ) activation and
ECM degradation by regulating podosome formation
Xiao et al., Ther Apher Dial 2010
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CTGF expression was increased after stimulation with TGF-beta1, but inhibited using each of the four independent CTGF shRNA constructs ( P < 0.01 ). Moreover, expression of
ECM proteins ( FN, col 1, and laminin ) and VEGF were upregulated after incubation with TGF-beta1, but elevated levels of ECM and
VEGF induced by TGF-beta1 were significantly
inhibited by RNAi ( P < 0.01 ), but not by the empty retroviral vector ( P > 0.05 )
Köhn-Luque et al., PloS one 2011
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In this study, we propose a mathematical model based on the alternative assumption that endodermal
VEGF signalling activity, having a paracrine effect on adjacent angioblasts, is
mediated by its binding to the
extracellular matrix ( ECM )