Gene interactions and pathways from curated databases and text-mining

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ECM2 — RELA

Text-mined interactions from Literome

Wang et al., J Cell Biochem 1999 : NFkappaB activation by ECM was necessary for cellular differentiation, rather than inhibition, of apoptosis
Ritchie et al., J Cell Physiol 2000 (Glioblastoma) : Accordingly, ectopic over-expression of NFkappaB subunits in GBM cells elevated the levels of fibronectin gene expression, providing direct evidence for a regulatory role for NF-kappaB in ECM protein production
Hammar et al., J Biol Chem 2005 : 804G-ECM induced nuclear translocation of NF-kappaB was weak as compared with that induced by interleukin-1beta ... Transient 804G-ECM induced DNA binding activity of NF-kappaB ( peak at 2 h ) and overexpression of NF-kappaB target genes IkappaB alpha and NF-kappaB1 ( p105 ) ( peak at 4 h ) were observed ... This study shows for the first time that ECM induced NF-kappaB activity is necessary in maintaining GSIS, although it does not affect survival of pancreatic beta cells ... The effects of ECM induced NF-kappaB activity contrast with the deleterious effects of cytokine induced NF-kappaB activity