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ECM2 — RELA
Text-mined interactions from Literome
Wang et al., J Cell Biochem 1999
:
NFkappaB activation by
ECM was necessary for cellular differentiation, rather than inhibition, of apoptosis
Ritchie et al., J Cell Physiol 2000
(Glioblastoma) :
Accordingly, ectopic over-expression of NFkappaB subunits in GBM cells elevated the levels of fibronectin gene expression, providing direct evidence for a regulatory
role for
NF-kappaB in
ECM protein production
Hammar et al., J Biol Chem 2005
:
804G-ECM induced nuclear translocation of
NF-kappaB was weak as compared with that induced by interleukin-1beta ... Transient
804G-ECM induced DNA binding activity of NF-kappaB ( peak at 2 h ) and overexpression of
NF-kappaB target genes IkappaB alpha and NF-kappaB1 ( p105 ) ( peak at 4 h ) were observed ... This study shows for the first time that
ECM induced
NF-kappaB activity is necessary in maintaining GSIS, although it does not affect survival of pancreatic beta cells ... The effects of
ECM induced
NF-kappaB activity contrast with the deleterious effects of cytokine induced NF-kappaB activity