Gene interactions and pathways from curated databases and text-mining

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EDN1 — MMP9

Text-mined interactions from Literome

Ergul et al., Am J Physiol Heart Circ Physiol 2003 (Hypertension) : However, little is known about endothelin (ET)-1 regulation of vascular MMP activity in hypertension
Roy-Beaudry et al., Arthritis Rheum 2003 (Osteoarthritis) : Recently, it was suggested that endothelin 1 (ET-1) , a potent vasoconstrictor, may be involved in MMP regulation
Tang et al., Pharmacol Rep 2008 (Cardiomyopathies...) : It has been verified that endothelin-1 (ET-1) activates matrix metalloproteinase ( MMP ) in the process of myocardial remodeling
Cheng et al., Acta Pharmacol Sin 2009 (Hypertrophy) : We hypothesized that dispersed NADPH oxidase, protein kinase Cepsilon ( PKCepsilon ), early response gene (ERG), and matrix metalloproteinase 9(MMP-9) across the heart by isoproterenol ( ISO ) medication might be mediated by the endothelin ( ET ) - ROS pathway