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APOB — EDN3

Text-mined interactions from Literome

Haug et al., J Mol Cell Cardiol 2001 : In the present study, we have investigated the effect of native LDL ( nLDL ) and oxidatively modified LDL ( oxLDL ) on ET-1 synthesis and endothelin receptor expression in cultured human coronary artery smooth muscle cells and human monocyte derived macrophages ... In coronary smooth muscle cells, endothelin A receptor expression was slightly increased by LDL , whereas endothelin A receptor was not detectable in monocyte derived macrophages
Bousette et al., Can J Physiol Pharmacol 2003 (Arteriosclerosis...) : We also discuss regulation of endothelin by angiotensin II, reactive oxygen species, thrombin, aging, and LDL in the cardiovascular system
Boulanger et al., Circ Res 1992 : The Ox-LDL stimulated release of endothelin was mimicked by acetylated low density lipoprotein and abolished by downregulation of protein kinase C by phorbol ester
Muller et al., Experimental biology and medicine (Maywood, N.J.) 2006 : Although it has been previously shown that hypercholesterolemia stimulates the endothelin system, the effects of increased levels of LDL on endothelial endothelin receptors have not been previously studied
He et al., Atherosclerosis 1996 : The aim of this study was to determine how oxidized LDL affects endothelin secretion by endothelial cells, monocytes and macrophages ... Extensively oxidized LDL inhibited endothelin secretion from cultured endothelial cells ... Acetyl LDL slightly increased basal endothelin release by endothelial cells, but native LDL or mildly oxidized LDL had no significant effect ... Overall, the present findings argue against a stimulatory effect of oxidized LDL on endothelin release as contributing to increased vasoreactivity in atherosclerosis