Shi-Wen et al., J Invest Dermatol 2001
(Scleroderma, Systemic) :
Conversely, endothelin-1 inhibited both protein expression of matrix metalloproteinase 1 and zymographic activity exclusively via ETA receptors
Spinella et al., Cancer Res 2007
(Melanoma...) :
ETs also increase HIF-1alpha expression under both normoxic and hypoxic conditions and its silencing by siRNA desensitizes COX-2 transcriptional activity, PGE ( 2 ) and VEGF production, and MMP activation in response to ET-3 , implicating, for the first time, HIF-1alpha/COX as downstream targets of ET ( B ) R signaling leading to invasiveness