Gene interactions and pathways from curated databases and text-mining

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EDN3 — MMP1

Text-mined interactions from Literome

Shi-Wen et al., J Invest Dermatol 2001 (Scleroderma, Systemic) : Conversely, endothelin-1 inhibited both protein expression of matrix metalloproteinase 1 and zymographic activity exclusively via ETA receptors
Spinella et al., Cancer Res 2007 (Melanoma...) : ETs also increase HIF-1alpha expression under both normoxic and hypoxic conditions and its silencing by siRNA desensitizes COX-2 transcriptional activity, PGE ( 2 ) and VEGF production, and MMP activation in response to ET-3 , implicating, for the first time, HIF-1alpha/COX as downstream targets of ET ( B ) R signaling leading to invasiveness