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EGFR — NFKB1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Habib et al., J Biol Chem 2001
:
Although previous studies have shown that the activated
EGFR can
induce NF-kappaB , the mechanism of this activation remains unknown ... Using a dominant negative NIK mutant, we show that NIK activation is required for
EGFR mediated
NF-kappaB induction ... We also show that a S32/36 IkappaBalpha mutant blocks
EGFR induced
NF-kappaB activation ... Finally, although protein kinase B/Akt has been implicated in tumor necrosis factor and PDGF induced NF-kappaB activation, our studies do not support a role for this protein in
EGFR induced
NF-kappaB activation
Hirota et al., FEBS Lett 2001
:
An endogenous redox molecule, thioredoxin, regulates transactivation of
epidermal growth factor receptor and
activation of
NF-kappaB by lysophosphatidic acid
Pianetti et al., Oncogene 2001
(Breast Neoplasms...) :
Overexpression of Her-2/neu and
EGFR-4 in Ba/F3 cells
led to constitutive PI3- and Akt kinase activities, and induction of classical
NF-kappaB ( p50/p65 )
Hirota et al., J Biol Chem 2001
:
Taken together, this evidence strongly suggests that
EGFR transactivation by TNF, which is regulated in a redox dependent manner, is playing a pivotal
role in TNF induced
NF-kappa B activation
Wu et al., Am J Physiol Lung Cell Mol Physiol 2002
(MAP Kinase Signaling System) :
EGFR signaling appears to cross talk with NF-kappaB signaling at the level of Ras, but additional signals appear
necessary for
NF-kappaB activation
Bancroft et al., Int J Cancer 2002
(Carcinoma, Squamous Cell...) :
Recombinant EGF induced
EGFR phosphorylation,
activation of
NF-kappaB and AP-1 reporter genes and IL-8 and VEGF expression, indicating that EGFR can mediate coactivation of both transcription factors and cytokine genes in HNSCC ... We conclude that antagonists of EGFR, PI3K and MEK signal pathways have inhibitory activity against
EGFR induced
NF-kappaB and AP-1 activation, IL-8 and VEGF expression and growth by HNSCC
Nishi et al., Int J Mol Med 2003
(Breast Neoplasms) :
However, it was found that
NF-kappaB could not
transactivate the
EGFR by cotransfection experiments with each NF-kappaB subunit, using p50, p65 and c-Rel and an EGFR promoter luciferase reporter
Yang et al., Mol Pharmacol 2003
:
The D2R mediated
NF-kappaB activation was not
dependent on
epidermal growth factor (EGF) receptor transactivation since 4- ( 3'-chloroanilino ) -6,7-dimethoxyquinazoline ( AG1478 ), an EGF receptor-selective tyrphostin used at 1 microM, blocked EGF induced NF-kappaB activation but not the quinpirole induced response
Kapoor et al., Mol Cell Biol 2004
(Glioblastoma) :
Although previous studies suggest that
EGFR can
induce NF-kappaB , the mechanism of this activation remains unknown ... We also show that
EGFR induced
NF-kappaB activation is mediated by the PI3-kinase/Akt activation loop ... Interestingly, overexpression of either one of the two SH2 domain mutants of SHP-2, R32E or R138E, slightly reduced NF-kappaB activity relative to that of wild-type SHP-2, indicating that the SH2 domains of SHP-2 are required for
EGFR induced
NF-kappaB activation
Tao et al., Cell Signal 2004
:
The Epstein-Barr virus ( EBV ) latent membrane protein 1 (LMP1) oncoprotein may cause multiple cellular changes including the induction of
epidermal growth factor receptor (EGFR) expression and
activation of the
NFkappaB transcription factor ... Taken together, Epstein-Barr virus latent membrane protein 1 modulated the
EGFR promoter activity in a
NFkappaB dependent manner
Tao et al., Virus Res 2004
:
The Epstein-Barr virus ( EBV ) latent membrane protein 1 (LMP1) oncoprotein may cause multiple cellular changes, including the induction of
epidermal growth factor receptor (EGFR) expression and the
activation of the
nuclear factor kappa B (NFkappaB) transcription factor
Le Page et al., Prostate 2005
(Prostatic Neoplasms) :
EGFR and Her-2
regulate the constitutive activation of
NF-kappaB in PC-3 prostate cancer cells ... Using several pharmacological ErbB inhibitors, we demonstrate that
EGFR and Her-2 are
involved in the constitutive activation of
NF-kappaB in PC-3 cells through two different mechanisms ...
EGFR activates
NF-kappaB through the phosphorylation of IkappaBalpha on serines 32/36 thereby influencing the nuclear translocation of the p65 subunit
Le Page et al., Prostate 2005
(Prostatic Neoplasms) :
Recent research has highlighted the potential
role of
EGFR and Her-2 in the constitutive activation of
NF-kappaB ( NF-kappaB ) in prostate cancer cells, although the mechanism by which these receptors activate NF-kappaB in these cells remains unclear ... Using pharmacological and genetic approaches we show that in PC-3 cells,
EGFR and Her-2 are
involved in the constitutive activation of
NF-kappaB through two different mechanisms ...
EGFR activates
NF-kappaB through the PI3K/Akt pathway that leads to the phosphorylation of IkappaBalpha on serines 32 and 36, thereby promoting the nuclear translocation of the p65 subunit
Kuwahara et al., Am J Physiol Lung Cell Mol Physiol 2006
:
We conclude that NE increases IL-8 transcription through
p38/NF-kappaB activation via
EGFR transactivation
Biswas et al., J Cell Physiol 2006
(Breast Neoplasms) :
This article is focused on the role of
NF-kappaB activation
initiated by the
EGFR family receptors in subclasses of breast cancer
An et al., Mol Cancer Ther 2007
(Carcinoma, Renal Cell...) :
Using pharmacologic and genetic approaches, we also showed that
EGFR mediated
NF-kappaB activation occurs through the phosphotidylinositol-3-OH kinase/AKT pathway
Sethi et al., Oncogene 2007
(Adenocarcinoma...) :
Overexpression of
epidermal growth factor (EGF) receptor and constitutive
activation of
nuclear factor-kappaB (NF-kappaB) are frequently encountered in tumor cells
Thornburg et al., J Virol 2007
:
Induction of
epidermal growth factor receptor expression by Epstein-Barr virus latent membrane protein 1 C-terminal activating region 1 is
mediated by
NF-kappaB p50 homodimer/Bcl-3 complexes ... In this study, the
role of
NF-kappaB p50 and Bcl-3 in LMP1 mediated upregulation of
EGFR was analyzed
Hsieh et al., J Cell Biochem 2008
:
Furthermore, S1P induced
EGFR upregulation was
blocked by a selective
NF-kappaB inhibitor helenalin
Lee et al., American journal of physiology. Renal physiology 2008
:
In conclusion, BSA stimulates DNA synthesis that is mediated by Ca ( 2+ ) /PKC as well as the
EGFR dependent p44/42 MAPK and
NF-kappaB signal pathways in PTCs
Hsieh et al., Biochim Biophys Acta 2008
:
Moreover, thrombin stimulated
activation of
NF-kappaB , AP-1, and COX-2 promoter activity was blocked by the inhibitors of c-Src, PKC,
EGFR , MEK1/2, AP-1 and NF-kappaB, suggesting that thrombin induces COX-2 promoter activity mediated through PKC ( delta ) /c-Src dependent EGFR transactivation, MEK-ERK1/2, AP-1, and NF-kappaB
Cao et al., Cell Signal 2008
:
Inhibition of
EGFR also
suppresses UV-induced activation of PI3K/AKT/mTOR/S6K and
NF-kappaB signal transduction pathways
Shant et al., Exp Cell Res 2009
(Colonic Neoplasms) :
We hypothesized that bile acid induced
EGFR activation also
mediates cell survival by downstream Akt regulated activation of
NF-kappaB ... Both DCT induced
NF-kappaB nuclear translocation and attenuation of TNF-alpha stimulated apoptosis were
dependent on
EGFR activation
Miller et al., Mol Cell Biol 1998
:
The Epstein-Barr virus latent membrane protein 1 (LMP1) oncoprotein causes multiple cellular changes, including induction of
epidermal growth factor receptor (EGFR) expression and
activation of the
NF-kappaB transcription factor
Miller et al., Oncogene 1998
(Nasopharyngeal Neoplasms) :
In this study, the LMP1 proteins derived from the laboratory strain B95-8 and the NPC strain C15 were analysed for their ability to activate
NF-kappa B and also to
induce expression of the
EGFR ... The data suggest that the C15-LMP1 protein activates
NF-kappa B more efficiently and
induces higher levels of the
EGFR ... Finally, these data provide evidence that five amino acid changes within the transmembrane domain in the C15-LMP1 protein lead to enhanced
NF-kappa B activation and
EGFR induction