Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
SMAD2
→
Complex of EP300-SMAD2
(directlyIncreases, EP300/SMAD2 Activity)
Ross et al., EMBO J 2006* Evidence: We demonstrate that Smad2-mediated transcription requires the histone acetyltransferase, p300. Smad2-recruited p300 exhibits an altered substrate specificity, specifically acetylating nucleosomal histone H3 at lysines 9 and 18, and these modifications are also detected on an endogenous Smad2-dependent promoter in a ligand-induced manner.