Gene interactions and pathways from curated databases and text-mining

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ERVK-6 — MMP15

Text-mined interactions from Literome

Heitzer et al., J Biol Chem 2002 : VMP3 shows proteinase activity and is inhibited by EDTA or the MMP inhibitor GM 6001, but in contrast to all known proteinases, VMP3 clearly prefers copper for activity rather than zinc
Houard et al., J Cell Biochem 2003 : However, this proteinase was not inhibited by an MMP inhibitor
Komori et al., J Toxicol Sci 2006 : In addition, the proteolytic activity was almost completely inhibited by BS-10, a MMP inhibitor , but not by the serine proteinase inhibitors, cysteine proteinase inhibitors and aspartic proteinase inhibitors
Tyagi et al., J Cell Physiol 1996 (Myocardial Infarction) : These results suggested that during ischemic cardiomyopathy, initially neutrophil proteinase activates latent myocardial MMP which can degrade ECM, which continuously degrades if not controlled by TIMP, leading to ventricular dilatation and dysfunction
DeCarlo et al., J Dent Res 1997 : In this article, we demonstrate that a proteinase isolated from the periodontopathogen Porphyromonas gingivalis can activate MMP-1, MMP-3 , and MMP-9 and can catalyze the superactivation of MMP-1 by MMP-3