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Gopalan et al., Cancer Res 2005
(Ovarian Neoplasms) :
Promoter based reporter gene analyses showed that Ad-mda7 specifically activated the Fas promoter
Park et al., Mol Cancer Ther 2009
(Carcinoma, Renal Cell) :
GST-MDA-7 caused plasma membrane clustering of CD95 and the association of CD95 with procaspase-8 ... Our data show that in kidney cancer cells GST-MDA-7 induces ceramide dependent activation of CD95 , which is causal in promoting an endoplasmic reticulum stress response that activates multiple proapoptotic pathways to decrease survival
Park et al., Mol Pharmacol 2011
(Carcinoma, Renal Cell...) :
Inhibition of ROS generation, elevated cytosolic Ca ( 2+ ), or de novo ceramide synthesis blocked Ad.5/3-mda-7 ± agent induced CD95 activation and the enhancement of apoptosis
Yamada et al., Diabetologia 1996
(Autoimmune Diseases...) :
Mouse islet cell lysis mediated by interleukin-1 induced Fas