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FLT4 — KDR

Pathways - manually collected, often from reviews:

• BioCarta vegf hypoxia and angiogenesis: VEGF/VEGF R complex (VEGF-FLT4_KDR_FLT1) → VEGF R (FLT4/KDR/FLT1) (modification, collaborate)
• NCI Pathway Database VEGF and VEGFR signaling network: VEGFA189 (dimer) complex (VEGFA) → VEGFR2/3 (dimer)/VEGFA189 (dimer) complex (FLT4-KDR-VEGFA) (modification, collaborate)
  Nilsson et al., EMBO J 2010
  Evidence: physical interaction
• NCI Pathway Database VEGF and VEGFR signaling network: VEGFR2/3 (dimer)/VEGFA189 (dimer) complex (FLT4-KDR-VEGFA) → VEGFR2 (KDR) (modification, collaborate) Nilsson et al., EMBO J 2010
  Evidence: physical interaction
• NCI Pathway Database VEGF and VEGFR signaling network: VEGFR2/3 (dimer)/VEGFA189 (dimer) complex (FLT4-KDR-VEGFA) → VEGFR3 (FLT4) (modification, collaborate) Nilsson et al., EMBO J 2010
  Evidence: physical interaction
• NCI Pathway Database VEGF and VEGFR signaling network: VEGFR2 (KDR) → VEGFR3 (FLT4) (modification, collaborate) Nilsson et al., EMBO J 2010
  Evidence: physical interaction
• NCI Pathway Database VEGF and VEGFR signaling network: VEGFR2/3/VEGFC (dimer) complex (FLT4-KDR-VEGFC) → VEGFC (dimer) complex (VEGFC) (modification, collaborate)
  Dixelius et al., J Biol Chem 2003, Alam et al., Biochem Biophys Res Commun 2004*, Nilsson et al., EMBO J 2010, Joukov et al., EMBO J 1997*, Fitz et al., Oncogene 1997*, Cao et al., Proc Natl Acad Sci U S A 1998*
  Evidence: physical interaction
• NCI Pathway Database VEGF and VEGFR signaling network: VEGFR2/3/VEGFC (dimer) complex (FLT4-KDR-VEGFC) → VEGFR2 (KDR) (modification, collaborate) Dixelius et al., J Biol Chem 2003, Alam et al., Biochem Biophys Res Commun 2004*, Nilsson et al., EMBO J 2010, Joukov et al., EMBO J 1997*, Fitz et al., Oncogene 1997*, Cao et al., Proc Natl Acad Sci U S A 1998*
  Evidence: physical interaction
• NCI Pathway Database VEGF and VEGFR signaling network: VEGFR2/3/VEGFC (dimer) complex (FLT4-KDR-VEGFC) → VEGFR3 (FLT4) (modification, collaborate) Dixelius et al., J Biol Chem 2003, Alam et al., Biochem Biophys Res Commun 2004*, Nilsson et al., EMBO J 2010, Joukov et al., EMBO J 1997*, Fitz et al., Oncogene 1997*, Cao et al., Proc Natl Acad Sci U S A 1998*
  Evidence: physical interaction
• NCI Pathway Database VEGF and VEGFR signaling network: VEGFR2 (KDR) → VEGFR3 (FLT4) (modification, collaborate) Dixelius et al., J Biol Chem 2003, Alam et al., Biochem Biophys Res Commun 2004*, Nilsson et al., EMBO J 2010, Joukov et al., EMBO J 1997*, Fitz et al., Oncogene 1997*, Cao et al., Proc Natl Acad Sci U S A 1998*
  Evidence: physical interaction
• NCI Pathway Database VEGF and VEGFR signaling network: NRP2 (NRP2) → VEGFR2/3 (dimer)/VEGFC (dimer)/NRP2 complex (FLT4-KDR-VEGFC-NRP2) (modification, collaborate)
  Favier et al., Blood 2006, Xu et al., J Cell Biol 2010*
  Evidence: physical interaction
• NCI Pathway Database VEGF and VEGFR signaling network: VEGFR2/3 (dimer)/VEGFC (dimer)/NRP2 complex (FLT4-KDR-VEGFC-NRP2) → VEGFR2 (KDR) (modification, collaborate) Favier et al., Blood 2006, Xu et al., J Cell Biol 2010*
  Evidence: physical interaction
• NCI Pathway Database VEGF and VEGFR signaling network: VEGFR2/3 (dimer)/VEGFC (dimer)/NRP2 complex (FLT4-KDR-VEGFC-NRP2) → VEGFC (dimer) complex (VEGFC) (modification, collaborate)
  Favier et al., Blood 2006, Xu et al., J Cell Biol 2010*
  Evidence: physical interaction
• NCI Pathway Database VEGF and VEGFR signaling network: VEGFR2/3 (dimer)/VEGFC (dimer)/NRP2 complex (FLT4-KDR-VEGFC-NRP2) → VEGFR3 (FLT4) (modification, collaborate) Favier et al., Blood 2006, Xu et al., J Cell Biol 2010*
  Evidence: physical interaction
• NCI Pathway Database VEGF and VEGFR signaling network: VEGFR2 (KDR) → VEGFR3 (FLT4) (modification, collaborate) Favier et al., Blood 2006, Xu et al., J Cell Biol 2010*
  Evidence: physical interaction
• NCI Pathway Database VEGF and VEGFR signaling network: VEGFA121 (dimer) complex (VEGFA) → VEGFR2/3 (dimer)/VEGFA121 (dimer) complex (FLT4-KDR-VEGFA) (modification, collaborate)
  Nilsson et al., EMBO J 2010
  Evidence: physical interaction
• NCI Pathway Database VEGF and VEGFR signaling network: VEGFR2/3 (dimer)/VEGFA121 (dimer) complex (FLT4-KDR-VEGFA) → VEGFR2 (KDR) (modification, collaborate) Nilsson et al., EMBO J 2010
  Evidence: physical interaction
• NCI Pathway Database VEGF and VEGFR signaling network: VEGFR2/3 (dimer)/VEGFA121 (dimer) complex (FLT4-KDR-VEGFA) → VEGFR3 (FLT4) (modification, collaborate) Nilsson et al., EMBO J 2010
  Evidence: physical interaction
• NCI Pathway Database VEGF and VEGFR signaling network: VEGFR2 (KDR) → VEGFR3 (FLT4) (modification, collaborate) Nilsson et al., EMBO J 2010
  Evidence: physical interaction
• NCI Pathway Database VEGF and VEGFR signaling network: VEGFA (dimer) complex (VEGFA) → VEGFR2/3 (dimer)/VEGFA (dimer) complex (FLT4-KDR-VEGFA) (modification, collaborate)
  Nilsson et al., EMBO J 2010
  Evidence: physical interaction
• NCI Pathway Database VEGF and VEGFR signaling network: VEGFR2/3 (dimer)/VEGFA (dimer) complex (FLT4-KDR-VEGFA) → VEGFR2 (KDR) (modification, collaborate) Nilsson et al., EMBO J 2010
  Evidence: physical interaction
• NCI Pathway Database VEGF and VEGFR signaling network: VEGFR2/3 (dimer)/VEGFA (dimer) complex (FLT4-KDR-VEGFA) → VEGFR3 (FLT4) (modification, collaborate) Nilsson et al., EMBO J 2010
  Evidence: physical interaction
• NCI Pathway Database VEGF and VEGFR signaling network: VEGFR2 (KDR) → VEGFR3 (FLT4) (modification, collaborate) Nilsson et al., EMBO J 2010
  Evidence: physical interaction
• NCI Pathway Database VEGF and VEGFR signaling network: VEGFR2/3 (dimer)/VEGFD (dimer) complex (FLT4-KDR-FIGF) → VEGFD (dimer) complex (FIGF) (modification, collaborate)
  Alam et al., Biochem Biophys Res Commun 2004*, Salameh et al., Blood 2005, Nilsson et al., EMBO J 2010
  Evidence: physical interaction
• NCI Pathway Database VEGF and VEGFR signaling network: VEGFR2/3 (dimer)/VEGFD (dimer) complex (FLT4-KDR-FIGF) → VEGFR2 (KDR) (modification, collaborate) Alam et al., Biochem Biophys Res Commun 2004*, Salameh et al., Blood 2005, Nilsson et al., EMBO J 2010
  Evidence: physical interaction
• NCI Pathway Database VEGF and VEGFR signaling network: VEGFR2/3 (dimer)/VEGFD (dimer) complex (FLT4-KDR-FIGF) → VEGFR3 (FLT4) (modification, collaborate) Alam et al., Biochem Biophys Res Commun 2004*, Salameh et al., Blood 2005, Nilsson et al., EMBO J 2010
  Evidence: physical interaction
• NCI Pathway Database VEGF and VEGFR signaling network: VEGFR2 (KDR) → VEGFR3 (FLT4) (modification, collaborate) Alam et al., Biochem Biophys Res Commun 2004*, Salameh et al., Blood 2005, Nilsson et al., EMBO J 2010
  Evidence: physical interaction
• NCI Pathway Database VEGF and VEGFR signaling network: VEGFA (dimer) complex (VEGFA) → VEGFR2/3 (dimer)/VEGFA (dimer)/NRP2 complex (FLT4-KDR-VEGFA-NRP2) (modification, collaborate)
  Favier et al., Blood 2006
  Evidence: physical interaction
• NCI Pathway Database VEGF and VEGFR signaling network: VEGFR2/3 (dimer)/VEGFA (dimer)/NRP2 complex (FLT4-KDR-VEGFA-NRP2) → NRP2 (NRP2) (modification, collaborate) Favier et al., Blood 2006
  Evidence: physical interaction
• NCI Pathway Database VEGF and VEGFR signaling network: VEGFR2/3 (dimer)/VEGFA (dimer)/NRP2 complex (FLT4-KDR-VEGFA-NRP2) → VEGFR2 (KDR) (modification, collaborate) Favier et al., Blood 2006
  Evidence: physical interaction
• NCI Pathway Database VEGF and VEGFR signaling network: VEGFR2/3 (dimer)/VEGFA (dimer)/NRP2 complex (FLT4-KDR-VEGFA-NRP2) → VEGFR3 (FLT4) (modification, collaborate) Favier et al., Blood 2006
  Evidence: physical interaction
• NCI Pathway Database VEGF and VEGFR signaling network: VEGFR2 (KDR) → VEGFR3 (FLT4) (modification, collaborate) Favier et al., Blood 2006
  Evidence: physical interaction
• NCI Pathway Database VEGF and VEGFR signaling network: VEGFA145 (dimer) complex (VEGFA) → VEGFR2/3 (dimer)/VEGFA145 (dimer) complex (FLT4-KDR-VEGFA) (modification, collaborate)
  Nilsson et al., EMBO J 2010
  Evidence: physical interaction
• NCI Pathway Database VEGF and VEGFR signaling network: VEGFR2/3 (dimer)/VEGFA145 (dimer) complex (FLT4-KDR-VEGFA) → VEGFR2 (KDR) (modification, collaborate) Nilsson et al., EMBO J 2010
  Evidence: physical interaction
• NCI Pathway Database VEGF and VEGFR signaling network: VEGFR2/3 (dimer)/VEGFA145 (dimer) complex (FLT4-KDR-VEGFA) → VEGFR3 (FLT4) (modification, collaborate) Nilsson et al., EMBO J 2010
  Evidence: physical interaction
• NCI Pathway Database VEGF and VEGFR signaling network: VEGFR2 (KDR) → VEGFR3 (FLT4) (modification, collaborate) Nilsson et al., EMBO J 2010
  Evidence: physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: KDR — FLT4 (in vitro) Alam et al., Biochem Biophys Res Commun 2004*
• IRef Intact Interaction: KDR — FLT4 (physical association, coimmunoprecipitation) Su et al., Cancer Cell 2006*
• IRef Intact Interaction: KDR — FLT4 (physical association, anti bait coimmunoprecipitation) Nilsson et al., EMBO J 2010
• IRef Intact Interaction: KDR — FLT4 (physical association, anti bait coimmunoprecipitation) Tvorogov et al., Cancer Cell 2010*

Text-mined interactions from Literome

Witmer et al., Invest Ophthalmol Vis Sci 2002 (Diabetic Retinopathy) : In diabetic eyes, expression of retinal VEGFR-2 and -3 is increased, mainly in leaky microvessels, and VEGF-A induces vascular expression of the VEGF-A receptor VEGFR-2 and the VEGF-C/D receptor VEGFR-3
Holmes et al., Cell Signal 2007 (Neoplasms) : VEGFR-1 is required for the recruitment of haematopoietic stem cells and the migration of monocytes and macrophages, VEGFR-2 regulates vascular endothelial function and VEGFR-3 regulates lymphatic endothelial cell function
Domigan et al., Curr Opin Hematol 2012 (Vascular Diseases) : In particular, we learned how VEGFR3 regulates Notch signaling and EphrinB2 coordinates VEGFR2 responses