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CDKN1A — FOXG1
Text-mined interactions from Literome
Arden et al., Mol Cell 2004
(Cell Transformation, Neoplastic) :
FoxG1 , a protein from a distinct Fox subfamily, binds FoxO/Smad complexes and
blocks p21Cip1 expression
Adesina et al., J Neurooncol 2007
(Brain Neoplasms...) :
Current reports indicate that
FOXG1 represses TGF-beta induced expression of
p21cip1 and cytostasis, and forms a transcriptional repressor complex with Notch signaling induced hes1
Chan et al., Br J Cancer 2009
(Ovarian Neoplasms) :
The
effect of
FOXG1 on
p21 ( WAF1/CIP1 ) transcriptional activity was examined by luciferase reporter assays ... Functionally, enforced expression of
FOXG1 selectively
blocked the TGF-beta induced
p21 ( WAF1/CIP1 ) expressions and increased cell proliferation in ovarian cancer cells