UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to NTF4

FRS2 — NTF4

Pathways - manually collected, often from reviews:

NCI Pathway Database SHP2 signaling: FRS2 family-active (FRS3/FRS2) → NGF/NGFR-active (NTRK1/NGF/NTF3/NTRK3/BDNF/NTRK2/NTF4/NTRK2) (modification, collaborate)
Dixon et al., Biochim Biophys Acta 2006, Hadari et al., Mol Cell Biol 1998
Evidence: mutant phenotype, physical interaction
NCI Pathway Database SHP2 signaling: NGF/NGFR-active (NTRK1/NGF/NTF3/NTRK3/BDNF/NTRK2/NTF4/NTRK2) → FRS2 family/SHP2 complex (FRS3_FRS2-PTPN11) (modification, activates)
Dixon et al., Biochim Biophys Acta 2006, Hadari et al., Mol Cell Biol 1998
Evidence: mutant phenotype, physical interaction
NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: FRS2 family-active (FRS3/FRS2) → NGF/NGFR-active (NTRK1/NGF/NTF3/NTRK3/BDNF/NTRK2/NTF4/NTRK2) (modification, collaborate)
Dixon et al., Biochim Biophys Acta 2006, Hadari et al., Mol Cell Biol 1998
Evidence: mutant phenotype, physical interaction
NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: NGF/NGFR-active (NTRK1/NGF/NTF3/NTRK3/BDNF/NTRK2/NTF4/NTRK2) → FRS2 family/SHP2 complex (FRS3_FRS2-PTPN11) (modification, activates)
Dixon et al., Biochim Biophys Acta 2006, Hadari et al., Mol Cell Biol 1998
Evidence: mutant phenotype, physical interaction
NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: NGF/NGFR-active (NTRK1/NGF/NTF3/NTRK3/BDNF/NTRK2/NTF4/NTRK2) → FRS2 family (FRS3/FRS2) (modification, activates) Meakin et al., J Biol Chem 1999, Ong et al., Mol Cell Biol 2000, Dixon et al., Biochim Biophys Acta 2006, Guiton et al., J Biol Chem 1995, Stephens et al., Neuron 1994, Obermeier et al., J Biol Chem 1993
Evidence: mutant phenotype, assay, physical interaction, other species
NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: FRS2 family-active (FRS3/FRS2) → NGF/NGFR-active (NTRK1/NGF/NTF3/NTRK3/BDNF/NTRK2/NTF4/NTRK2) (modification, collaborate)
Dixon et al., Biochim Biophys Acta 2006, Kouhara et al., Cell 1997
Evidence: mutant phenotype, physical interaction, other species
NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: NGF/NGFR-active (NTRK1/NGF/NTF3/NTRK3/BDNF/NTRK2/NTF4/NTRK2) → FRS2 family/GRB2/SOS1 complex (GRB2-SOS1-FRS3_FRS2) (modification, activates)
Dixon et al., Biochim Biophys Acta 2006, Kouhara et al., Cell 1997
Evidence: mutant phenotype, physical interaction, other species
NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: NGF/NGFR-active (NTRK1/NGF/NTF3/NTRK3/BDNF/NTRK2/NTF4/NTRK2) → FRS2 family/SHP2 complex (FRS3_FRS2-PTPN11) (modification, activates)
Kao et al., J Biol Chem 2001
Evidence: physical interaction