Gene interactions and pathways from curated databases and text-mining

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G6PD — INS

Text-mined interactions from Literome

Aquila et al., Endocrinology 2005 : The simultaneous decrease in both insulin release and glucose-6-phosphate dehydrogenase activity induced by blocking the autocrine insulin effect with three different procedures ( blockage of insulin release by nifedipine, immune neutralization of the released insulin by antiinsulin serum, and blockage of an insulin intracellular effector such as phosphotidylinositol 3-kinase by wortmannin ) strongly suggests a physiological role of sperm insulin on these two events
Park et al., Mol Cell Biol 2005 (Insulin Resistance...) : In accordance with these results, overexpression of G6PD impaired insulin signaling and suppressed insulin dependent glucose uptake in adipocytes
Talukdar et al., J Biol Chem 2005 : Arachidonic acid inhibits the insulin induction of glucose-6-phosphate dehydrogenase via p38 MAP kinase ... Arachidonic acid decreases the insulin induction of G6PD expression ; by itself, arachidonic acid does not inhibit basal G6PD mRNA accumulation
Matzen et al., Thyroidology / A.P.R.I.M 1991 : The T3 modulation of nuclear T3 binding ( NBT3 ), the T3 effect on cell growth, and the T3 and insulin effects on malic enzyme ( ME ), glucose-6-phosphat-dehydrogenase (G6PD) and 6-phosphogluconat-dehydrogenase ( G6PD ) were studied in a human hepatocyte cell-line ( Chang-liver )
Kohan et al., Biochem Biophys Res Commun 2009 : Activation of AMPK mimics the inhibition by arachidonic acid of the insulin mediated induction of G6PD
Zhang et al., FASEB J 2010 (Diabetes Mellitus, Type 2...) : Inhibition of G6PD with siRNA led to increased ROS and apoptosis, decreased proliferation, and impaired insulin secretion
Manos et al., Biochem J 1991 : Five modulators implicated in G6PD induction in vivo were examined : insulin , dexamethasone, tri-iodothyronine ( T3 ), glucose and fructose, T3 did not affect G6PD activity, and did not interact with carbohydrate to affect the activity of G6PD ... Insulin causes an additional 2-3-fold increase in G6PD synthesis and mRNA
Hecker et al., Am J Physiol Endocrinol Metab 2012 (Body Weight...) : G6PD deficiency did not affect glucose tolerance or the increased insulin levels seen in WT mice
Muthulakshmi et al., Biochimie 2013 (Diabetes Mellitus, Experimental...) : Among the three doses, 80 mg/kg BW of AzA was able to positively regulate plasma glucose, insulin , blood HbA1c and haemoglobin levels by significantly increasing the activity of hexokinase and glucose-6-phosphate dehydrogenase and significantly decreasing the activity of glucose-6-phosphatase and fructose-1,6-bisphosphatase thereby increasing the glycogen content in the liver
Katsurada et al., Biochim Biophys Acta 1989 (Diabetes Mellitus, Experimental) : Effects of nutrients and insulin on transcriptional and post-transcriptional regulation of glucose-6-phosphate dehydrogenase synthesis in rat liver
Salati et al., Lipids 1988 : Free fatty acid inhibition of the insulin induction of glucose-6-phosphate dehydrogenase in rat hepatocyte monolayers ... G6PD activity in cultured hepatocytes was induced several-fold by insulin ... Dexamethasone or T3 did not amplify the insulin induction of G6PD ... Insulin in combination with glucose induced G6PD an additional two-fold
Kobayashi et al., Acta Med Okayama 1988 : Insulin increased the activities of glucokinase ( EC 2.7.1.1 ), phosphofructokinase ( EC 2.7.1.11 ), pyruvate kinase ( EC 2.7.1.40 ) type L and glucose 6-phosphate dehydrogenase ( EC 1.1.1.49 )
Martins et al., Mol Cell Biochem 1986 (Diabetes Mellitus, Experimental) : Insulin , when administered together with adrenaline, restored hepatic glucose 6-phosphate dehydrogenase and phosphogluconate dehydrogenase activities of diabetic animals to control values, without altering food consumption
Martins et al., Biochem Biophys Res Commun 1985 : Regulation of the multiple molecular forms of rat liver glucose 6-phosphate dehydrogenase by insulin and dietary restriction
Kukulansky et al., Horm Metab Res 1979 (Diabetes Mellitus, Experimental...) : On the effect of insulin on glucose-6-phosphate dehydrogenase and fatty acid synthetase activity in mouse liver
Vinogradov et al., Vopr Med Khim 1980 : [ Regulation of glucose-6-phosphate dehydrogenase activity in rat liver by insulin and hydrocortisone ] ... The data obtained suggest that the activation and inhibition of G6PD by insulin and hydrocortisone, respectively, are due most likely not to alterations in conformation of the enzymatic molecules, but to the opposite influence of these hormones on the content of the main fraction of the isoenzyme spectrum of G6PD, which accounts for 78-90 % of its total activity
Nakamura et al., J Biochem 1982 : In primary cultured monolayer hepatocytes of adult rats, insulin ( 1 x 10 ( -8 ) M ) induced glucose-6-phosphate dehydrogenase [ EC 1.1.1.49, G6PDH ] several fold in 48 h
Geisler et al., Biochim Biophys Acta 1978 : Insulin increased the relative rate of synthesis of glucose-6-phosphate dehydrogenase by two-fold in tissue obtained from normal rats ... In the presence of insulin, the rate constant of degradation of total protein in adipose tissue was unchanged ; therefore the effects of insulin on the degradation of glucose-6-phosphate dehydrogenase are specific to that protein and perhaps to a few other specific proteins
Iwakiri et al., Metabolism 1995 (Diabetes Mellitus, Experimental) : Insulin treatment for 7 consecutive days increased hepatic G6PD activity by fourfold but was without effect on intestinal G6PD, suggesting tissue specificity in insulin regulation of G6PD
Taniguchi et al., J Nutr Sci Vitaminol (Tokyo) 1994 : Insulin response to glucose-6-phosphate dehydrogenase activity is elevated in rats fed diets low in polyunsaturated fatty acids
Molero et al., Exp Cell Res 1994 : Dexamethasone repressed the G6PD mRNA expression induced by glucose and insulin and decreased this expression when induced by T3, regardless of the presence of insulin
Wagle et al., J Biol Chem 1998 : Insulin regulation of glucose-6-phosphate dehydrogenase gene expression is rapamycin-sensitive and requires phosphatidylinositol 3-kinase
Gupta et al., Biochem Mol Biol Int 1998 (Diabetes Mellitus, Experimental) : The activities of hexokinase ( HK ) and glucose-6-phosphate dehydrogenase ( G-6PDH ) were increased in reticulocyte hemolysate isolated from the diabetic rats and were restored to normal levels by insulin