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GNRH1 — MMP2

Text-mined interactions from Literome

Goto et al., J Endocrinol 1999 : In this study we assessed the effect of GnRH on MMP expression and induction of structural involution of developed corpora lutea of superovulated rats using GnRHa
Huang et al., Int J Cancer 2002 (Carcinoma, Squamous Cell...) : LHRH reduced both basal and EGF stimulated secretion of MMP-9 and MMP-2
Chou et al., J Clin Endocrinol Metab 2003 : GnRH was capable of increasing MMP-2 and MMP-9 mRNA levels in these primary cell cultures in a dose dependent manner ... The GnRH antagonist, antide, was capable of inhibiting the GnRH mediated increase in the levels of the MMP-2 and MMP-9 mRNA transcripts present in these decidual stromal cells in a dose dependent manner
Chou et al., J Clin Endocrinol Metab 2003 : Regulatory effects of gonadotropin releasing hormone (GnRH) I and GnRH II on the levels of matrix metalloproteinase (MMP)-2 , MMP-9, and tissue inhibitor of metalloproteinases-1 in primary cultures of human extravillous cytotrophoblasts ... Cetrorelix, a GnRH receptor antagonist, inhibited the regulatory effects of GnRH I , but not GnRH II, on MMP-2 , MMP-9, and TIMP-1 expression in these cells ... Collectively, these observations suggest that GnRH I and GnRH II differentially regulate MMP-2 , MMP-9, and TIMP-1 expression in human trophoblasts, possibly via distinct receptor mediated intracellular signaling pathways
Cheung et al., Cancer Res 2006 (Neoplasm Invasiveness...) : Knockdown of the GnRH receptor using small interfering RNA significantly inhibited the GnRH induced MMP activation, invasion, and migration ... In addition, we showed that the c-Jun NH ( 2 ) -terminal kinase, but not extracellular signal regulated kinase 1/2 or p38 mitogen activated protein kinase, signaling pathway was critical for GnRH mediated up-regulation of MMP , cell invasion, and motility
Wu et al., BMC cancer 2013 : Gonadotropin releasing hormone type II ( GnRH-II ) agonist regulates the invasiveness of endometrial cancer cells through the GnRH-I receptor and mitogen activated protein kinase ( MAPK ) -dependent activation of matrix metalloproteinase (MMP)-2