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GP2 — NOS2

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Lee et al., Food Chem Toxicol 2007 (Colitis) : In addition, the results obtained from electrophoretic mobility shift assay ( EMSA ) and western blot analysis showed that UDN glycoprotein dose-dependently inhibits DNA binding activity of nuclear factor-kappa B (NF-kappaB), and activities of inducible nitric oxide synthase (iNOS) , cyclooxygenase-2 (COX-2), and manganese-superoxide dismutases ( Mn-SOD ) in LPS stimulated RAW 264.7 cells
Lee et al., Inflamm Res 2009 (Inflammation...) : In addition, ZPDC glycoprotein ( 200 microg/ml ) not only diminished the production of superoxide anion, hydrogen peroxide, and nitric oxide, but also suppressed the expression of pro-inflammatory cytokines ( IL-1 beta, IL-6, and TNF-alpha ) and proteins ( iNOS , COX-2, and MMP-9 ) in LPS- stimulated RAW 264.7 cells
Nawa et al., Life Sci 2010 (Body Weight...) : Inducible nitric oxide synthase mediated decrease of intestinal P-glycoprotein expression under streptozotocin induced diabetic conditions
Lee et al., Mol Cell Biochem 2012 : Taken together, these data indicate that the SJSZ glycoprotein prevents expression of COX-2, iNOS , and IL-1ß by blocking NF-?B and MAPKs in Cr ( VI ) -induced BNL CL.2 cells
Lee et al., Mol Cell Biochem 2013 (Carcinoma, Hepatocellular...) : The results revealed that the SJSZ glycoprotein ( 10 mg/kg, BW ) inhibits the phosphorylation of MAPKs and expression of NF-?B, pSTAT6, IL-10, and IL-4 ; and normalizes production of ROS and NO, and expression of iNOS , IL-12, and IFN-?