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AKT2 — GP6

Text-mined interactions from Literome

Xiong et al., J Cell Physiol 2009 : Dystrophin glycoprotein complex associated Gbetagamma subunits activate phosphatidylinositol-3-kinase/Akt signaling in skeletal muscle in a laminin dependent manner
Kim et al., J Biol Chem 2009 : Thus, we investigated the contribution of PI3K isoforms to GPVI mediated platelet activation and Akt activation ... A protein kinase C inhibitor GF 109203X or a P2Y ( 12 ) receptor antagonist AR-C69931MX partly reduced GPVI induced Akt phosphorylation ... Platelets from mice dosed with clopidogrel also showed partial Akt phosphorylation, indicating that GPVI mediated Akt phosphorylation is regulated by both secretion dependent and -independent pathways ... In addition, GPVI induced Akt phosphorylation in the presence of ADP antagonists was completely inhibited by PI3K inhibitor LY294002 and PI3Kbeta inhibitor TGX-221 indicating an essential role of PI3Kbeta in Akt activation directly downstream of GPVI ... These results demonstrate that GPVI induced Akt activation in platelets is dependent in part on G ( i ) stimulation through P2Y(12) receptor activation by secreted ADP ... In addition, a significant portion of GPVI dependent, ADP independent Akt activation also exists, and PI3Kbeta plays an essential role in GPVI mediated platelet aggregation and Akt activation