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Peterson et al., Mol Cell Biol 2007
(Breast Neoplasms) :
SMRT is
required for full expression of the
ERalpha target genes cyclin D1, BCL-2, and progesterone receptor but not pS2, and its depletion significantly attenuated estrogen dependent proliferation of MCF-7 cells
Karmakar et al., Mol Endocrinol 2010
(Breast Neoplasms) :
Our data link the SMRT corepressor directly with SRC family coactivators in positive regulation of ERalpha dependent gene expression and, taken with the positive correlation found for SMRT and SRC-3 in human breast tumors, suggest that
SMRT can
promote ERalpha- and SRC-3 dependent gene expression in breast cancer