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AKT2 — GRK6

Text-mined interactions from Literome

Kurose et al., Nihon Yakurigaku Zasshi 1999 (Myocardial Reperfusion Injury) : Expression of GRK2-ct inhibited the H2O2 induced activation of ERK by 70 % and also inhibited the activation of Akt by 30 %
Liu et al., Nat Med 2005 (Hypertension, Portal) : Furthermore, GRK2 expression increased in sinusoidal endothelial cells from portal hypertensive rats and knockdown of GRK2 restored Akt phosphorylation and NO production, and normalized portal pressure
Zheng et al., Proc Natl Acad Sci U S A 2012 : By suppressing GRK expression with siRNA, we demonstrated that lowering GRK5/6 abolishes IGF1 mediated ERK and AKT activation, whereas GRK2 inhibition increases ERK activation and partially inhibits AKT signaling