Shahid et al., J Biol Chem 2007
:
Insulin caused an increase in the translocation of GRK-2 from cytosol to the plasma membrane
Banday et al., American journal of physiology. Renal physiology 2007
:
Insulin increased protein kinase C ( PKC ) activity and caused G protein coupled receptor kinase 2 ( GRK2 ) translocation to the membranes ... Tyrosine kinase inhibitor genistein and phosphatidylinositol 3-kinase (PI3K) inhibitor wortmannin blocked insulin mediated PKC activation and GRK2 membranous translocation
Ciccarelli et al., Circulation 2011
(Heart Failure...) :
Importantly, inhibition of GRK2 activity prevents postischemic defects in myocardial insulin signaling and improves cardiac metabolism via normalized glucose uptake, which appears to participate in GRK2 targeted prevention of heart failure