Gene interactions and pathways from curated databases and text-mining

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GZMB — IL12A

Text-mined interactions from Literome

Marshall et al., J Immunol 2010 (Arenaviridae Infections) : IL-12 , IL-15, IL-18, and IFN-gamma were not individually required for sensitization to produce IFN-gamma, but IL-15 was required for upregulation of granzyme B
Hwang et al., PloS one 2012 (Influenza, Human) : Analysis of cytokine receptor deficient mice demonstrated that type I interferons ( IFNs ), but not IL-12 or IL-18, were critical for the NK cell expression of both IFN-? and granzyme B in response to flu infection
Chouaib et al., Proc Natl Acad Sci U S A 1994 : IL-12 increased granzyme B and perforin mRNA accumulation in major histocompatibility complex class I-primed lymphocytes, suggesting that this cytokine activates these two genes in CTL precursors
Aste-Amezaga et al., Cell Immunol 1994 : IL-12 induction of perforin mRNA accumulation was not synergistic with either IL-2 or anti-CD16 stimulation, whereas granzyme B mRNA accumulation, induced by IL-2 or anti-CD16 stimulation, was slightly potentiated by IL-12