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HBEGF — NOS3
Text-mined interactions from Literome
Mehta et al., Growth Factors 2007
(MAP Kinase Signaling System) :
HB-EGF- and EGF induced HUVEC migration and capillary tube formation were
dependent upon activation of PI3K, MAPK and
eNOS
Mehta et al., Growth Factors 2008
:
HB-EGF stimulates
eNOS expression and nitric oxide production and promotes eNOS dependent angiogenesis ... However, the
role of
HB-EGF in regulation of
eNOS has not yet been investigated ...
HB-EGF significantly upregulated expression of eNOS mRNA,
stimulated eNOS protein production, and increased NO release from HUVEC
Nakai et al., J Dermatol Sci 2009
:
HB-EGF induced VEGF production and
eNOS activation depend on both PI3 kinase and MAP kinase in HaCaT cells ... Although endothelial nitric oxide synthase (eNOS) and vascular endothelial growth factor ( VEGF ) appear to be involved in mitogenesis and chemotaxis in epidermal keratinocytes, the activation of
eNOS and VEGF production
induced by
HB-EGF and its signaling mechanism remains undefined ... We examined possible signal transduction pathways by which
HB-EGF leads to
eNOS activation and VEGF production in human epidermal keratinocyte cell line ( HaCaT cells ) ... The
HB-EGF induced
eNOS activation was significantly blocked by the p42/p44 MAPK inhibitor U0126 and the phosphatidylinositol 3-kinase ( P13K ) inhibitor LY294002 ... Finally, the
HB-EGF induced
activation of Akt and
eNOS was suppressed by VEGF competitive antagonist, CBO-P11 ... These results demonstrate that
HB-EGF induced
eNOS activation depends on p42/p44 MAPK, PI3K/Akt pathways and endogenous VEGF in HaCaT cells