Gene interactions and pathways from curated databases and text-mining

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HBEGF — NOS3

Text-mined interactions from Literome

Mehta et al., Growth Factors 2007 (MAP Kinase Signaling System) : HB-EGF- and EGF induced HUVEC migration and capillary tube formation were dependent upon activation of PI3K, MAPK and eNOS
Mehta et al., Growth Factors 2008 : HB-EGF stimulates eNOS expression and nitric oxide production and promotes eNOS dependent angiogenesis ... However, the role of HB-EGF in regulation of eNOS has not yet been investigated ... HB-EGF significantly upregulated expression of eNOS mRNA, stimulated eNOS protein production, and increased NO release from HUVEC
Nakai et al., J Dermatol Sci 2009 : HB-EGF induced VEGF production and eNOS activation depend on both PI3 kinase and MAP kinase in HaCaT cells ... Although endothelial nitric oxide synthase (eNOS) and vascular endothelial growth factor ( VEGF ) appear to be involved in mitogenesis and chemotaxis in epidermal keratinocytes, the activation of eNOS and VEGF production induced by HB-EGF and its signaling mechanism remains undefined ... We examined possible signal transduction pathways by which HB-EGF leads to eNOS activation and VEGF production in human epidermal keratinocyte cell line ( HaCaT cells ) ... The HB-EGF induced eNOS activation was significantly blocked by the p42/p44 MAPK inhibitor U0126 and the phosphatidylinositol 3-kinase ( P13K ) inhibitor LY294002 ... Finally, the HB-EGF induced activation of Akt and eNOS was suppressed by VEGF competitive antagonist, CBO-P11 ... These results demonstrate that HB-EGF induced eNOS activation depends on p42/p44 MAPK, PI3K/Akt pathways and endogenous VEGF in HaCaT cells