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HDAC1 — NOTCH2

Text-mined interactions from Literome

Hughes et al., Cancer Treat Res 2009 (Bone Neoplasms...) : Further, exposure to valproic acid at therapeutic concentrations induced expression of Notch genes and caused a 250-fold increase in invasiveness for non-invasive cell lines, but had no discernible effect on those lines that expressed high levels of Notch without valproic acid treatment, suggesting a role for HDAC in regulating Notch pathway expression in osteosarcoma
Mulligan et al., Mol Cell 2011 : A SIRT1-LSD1 corepressor complex regulates Notch target gene expression and development
Tang et al., Journal of the American Heart Association 2012 : However, inhibition of HDAC activity did not suppress Notch activation of the HRT target genes ... Although CBF-1 mediated Notch signaling was increased by HDAC inhibition in human SMCs and in a C3H10T1/2 model, SMC differentiation was inhibited in both cases ... Although CBF-1 mediated Notch signaling is not suppressed by HDAC inhibition, HDAC activity is required for Notch differentiation signals through mitogen activated protein kinase and PI3K pathways in SMCs. ( J Am Heart Assoc. 2012 ; 1 : e000901 doi : 10.1161/JAHA.112.000901 )
Zhao et al., Neoplasia (New York, N.Y.) 2013 : We showed that hD1R could bind to ECs specifically through its RGD motif and effectively triggered Notch signaling in ECs