Gene interactions and pathways from curated databases and text-mining

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HDAC2 — OPN1LW

Text-mined interactions from Literome

Lu et al., J Biol Chem 2003 : Although inhibition of histone deacetylase activity results in an increase of CREB- or CBP mediated gene expression, mutation of all three putative acetylation sites in the CREB activation domain markedly enhances the ability of CREB to activate a cAMP-responsive element dependent reporter gene
Yun et al., J Nutr Biochem 2011 (Diabetes Mellitus, Type 2) : Curcumin treatment also significantly reduced HAT activity, level of p300 and acetylated CBP/p300 gene expression, and induced HDAC2 expression by curcumin
Suzuki et al., J Biol Chem 2011 (Cell Transformation, Neoplastic...) : Furthermore, the inhibition of MEK or HDAC restored Cbp expression in human cancer cells harboring Cbp down-regulation through promoter hypomethylation