Gene interactions and pathways from curated databases and text-mining

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HDAC8 — TP53

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Wilkinson et al., Mol Cell Biol 2005 : p53 promotes SnoN and histone deacetylase interaction at an overlapping Smad binding, p53 regulatory element ( SBE/p53RE ) in AFP
Blagosklonny et al., Cancer Res 2005 : We suggest that, by either restoring or mimicking p53 trans-functions, histone deacetylase inhibitors initiate degradation of mutant p53
Chang et al., J Virol 2008 : Critical role of p53 in histone deacetylase inhibitor induced Epstein-Barr virus Zta expression
Chen et al., EMBO J 2010 : MDM2 also inhibits p53 transcriptional activity by recruiting histone deacetylase and corepressors to p53
Yan et al., Oncogene 2013 : Importantly, we found that upon knockdown of each class I HDAC, only HDAC8 knockdown leads to decreased expression of wild-type and mutant p53 proteins and transcripts ... Conversely, we found that ectopic expression of wild-type, but not mutant HDAC8 , leads to increased transcription of p53 ... Because of the fact that HDAC8 is required for expression of both wild-type and mutant p53 , we found that targeted disruption of HDAC8 expression remarkably triggers proliferative defect in cells with a mutant, but not wild-type, p53