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HGF — MMP9

Text-mined interactions from Literome

Horie et al., J Urol 1999 (Carcinoma, Renal Cell...) : The effects of HGF on in vitro chemoinvasion assay and the expression of matrix metalloproteinase-9 (MMP-9) , and the induction of Fas induced apoptosis were studied by transfection of HGF cDNA to cultured RCC cells, Caki-1
Hamasuna et al., Int J Cancer 1999 (Brain Neoplasms...) : MT1 -MMP , a cell-surface activator of proMMP-2, was also up-regulated by HGF/SF in a dose dependent manner
Hanzawa et al., Carcinogenesis 2000 (Carcinoma, Squamous Cell...) : Here we examined the effect of HGF on E1AF and MMP gene expression in terms of the invasive potential of the oral squamous cell carcinoma cell line HSC3
Haruyama et al., Biochem Biophys Res Commun 2000 : Interestingly, both the induced MMP-9 expression and hepatocyte proliferation by TNFalpha were synergistically enhanced by HGF in vitro
Wang et al., Biochem Biophys Res Commun 2000 (MAP Kinase Signaling System) : Hepatocyte growth factor enhances MMP activity in human endothelial cells
McCawley et al., Mol Pharmacol 2000 (MAP Kinase Signaling System) : Concentrations of forskolin that inhibit growth factor induced motility also eliminate EGF- or scatter factor/hepatocyte growth factor dependent induction of the 92-kDa gelatinase/MMP-9
Bennett et al., Eur J Oral Sci 2000 (Carcinoma, Squamous Cell...) : Metalloproteinase expression in normal and malignant oral keratinocytes : stimulation of MMP-2 and -9 by scatter factor
Imafuku et al., Clin Chim Acta 2002 : We also found a definite effects on copper, angiotensin converting enzyme (ACE), matrix metalloproteinase (MMP)-1 , -3 and -9, tissue inhibitor of matrix metalloproteinase ( TIMP ) -1, hepatocyte growth factor (HGF) , monoamine oxidase ( MAO ), vitamin B ( 12 ), ACTH and IL-6, though the mechanisms were not clear
Daniels et al., Invest Ophthalmol Vis Sci 2003 : HCEC migration ( P < 0.05 ) and MMP-2 and -9 released into the medium increased in response to HGF in a dose dependent manner up to 20 ng/mL
Hirata et al., Biol Reprod 2003 : Membrane type-1 MMP mRNA expression in the stromal cells was augmented by tumor necrosis factor alpha (TNFalpha), IL-6, HGF , and 12-O-tetradecanoylphorbol 13-acetate
Park et al., Int J Gynecol Cancer 2003 (Adenocarcinoma...) : HGF strongly induced MMP-9 mRNA expression in stromal cells, but had little effect on MMP-2 mRNA ... Zymographic analysis of MMPs showed that activation of MMP-2 and -9 was enhanced by HGF ... The effect of HGF on the invasiveness of 3D cocultured endometrial cancer cells and stromal cells appears to be due to induction of MMP-9 mRNA expression in stromal cells and /or increased activation of MMP-2 and MMP-9 by proteolytic digestion
Hah et al., Biochem Biophys Res Commun 2003 (Carcinoma, Hepatocellular...) : Moreover, the MMP-9 induction by HGF and TNF-alpha was also completely inhibited by GF109203X and sulfasalazine, but not by PD98059 and U0126
Fujiuchi et al., Oncol Rep 2003 (Neoplasm Invasiveness...) : Furthermore, HGF also increased the production of MMP-1 and -9, MT1-MMP , u-PA and uPAR of these cells
Gong et al., J Am Soc Nephrol 2003 (Disease Progression...) : In addition, HGF induced the production of MMP-9
Bredin et al., Anticancer Res 2003 (Carcinoma, Non-Small-Cell Lung...) : IGF I, IGF II, HGF and EGF stimulated an enhanced expression and activity of the latent form of MMP-2 and MMP-9
Bandow et al., J Cell Physiol 2004 : The results showed that HGF , but not FGF-2, stimulated MMP-9 expression, and that the stimulation was mediated through the activation of phosphoinositide 3-kinase (PI3K) which was not associated with FGF-2 signal transduction
Liu et al., Zhejiang Da Xue Xue Bao Yi Xue Ban 2004 : To investigate the stimulating effect of recombinant human hepatocyte growth factor ( rhHGF ) on the expression of matrix metalloproteinase-9 (MMP-9) in ECV304 cells and the suppression effect of FK506
Mizuno et al., FASEB J 2005 (Pulmonary Fibrosis) : For the myofibroblast-like cells, HGF increased activities of MMP-2/-9 , predominant enzymes for breakdown of fibronectin ( FN )
Li et al., World J Gastroenterol 2005 (Colorectal Neoplasms...) : Compared with controls, MMP-2 and MMP-9 mRNA expressions were up-regulated by HGF ( 0.997+/-0.011 vs 1.207+/-0.003, t = 35.002,P = 0.001 < 0.01 ; 0.387+/-0.128 vs 0.971+/-0.147, t = 106.036, P = 0.0000 < 0.01, respectively ) ; compared with controls, TIMP-1, TIMP-2 mRNA expressions were increased by PD98059 ( 1.344+/-0.007 vs 1.905+/-0.049, t = 17.541, P = 0.003 < 0.01 ; 1.286+/-0.020 vs 1.887+/-0.022,t = 24.623, P = 0.002 < 0.01, respectively )
Ide et al., Int J Cancer 2006 (Neoplasm Invasiveness...) : Conversely, the elevated cancer invasion, MMP activity and c-Met phosphorylation of PK8 cells were reduced by the removal of HGF from hypoxic conditioned medium
Higashiyama et al., Hepatology 2007 (Liver Cirrhosis...) : Experiments using transgenic mice overexpressing hepatocyte growth factor (HGF) indicated that G-CSF and HGF synergistically increased MMP-9 expression along the fibrous septa
Wang et al., Cancer Lett 2007 (Neoplasm Invasiveness...) : CHM-1 was identified from 2-phenyl-4-quinolone derivatives to potently inhibit HGF induced cell invasion, proteolytic activity, and expression of MMP-9
Lim et al., Cancer Lett 2008 (Hypopharyngeal Neoplasms...) : We also observed that HGF enhanced the activity of matrix metalloproteinase (MMP)-9 and urokinase-type plasminogen activator ( uPA ) in hypopharyngeal carcinoma cells ... On the other hand, EGCG at physiologically relevant concentration ( 1 microM ) suppressed HGF induced tumor motility and MMP-9 and uPA activities, and the suppression of Akt and Erk pathway by EGCG was one of the downstream mechanisms to facilitate EGCG induced anti-invasion effects
Guo et al., Cytotherapy 2008 (Cardiomyopathies...) : Furthermore, HGF induced expression of VCAM-1, and HGF treatment together with G-CSF synergistically stimulated MMP-9 expression in ischemic hearts
Jalili et al., Stem Cells Dev 2010 : Like G-CSF, HGF increased the secretion of MMP-9 and the expression of MT1-MMP in leukocytes, which was abrogated by the c-Met inhibitor K-252a
Lee et al., Oncol Res 2009 (MAP Kinase Signaling System...) : HGF induced Kiss-1 and MMP-9 production in a dose dependent manner
Lee et al., Mol Cell Biochem 2010 (Stomach Neoplasms) : These results demonstrated that HDACs regulate HGF induced uPA and MMP-9 expression through a PKC dependent signal pathway in gastric cancer cells
Wei-wei et al., Chin Med Sci J 2011 (Acute Lung Injury) : Contrary regulation of TIMP-1 and MMP-9 by hepatocyte growth factor antibody after lung injury
Dunsmore et al., J Biol Chem 1996 : Expression of 92-kDa gelatinase was not affected by HGF/SF
Aparicio et al., C R Seances Soc Biol Fil 1998 (Colonic Neoplasms...) : After 24 or 48 h of culture in medium supplemented with HGF, transforming growth factor-alpha ( TGF-alpha ) or sodium butyrate, MMP production by DHD/K12 cells was stimulated by HGF and TGF-alpha and inhibited by sodium butyrate
McCawley et al., J Biol Chem 1999 : We have shown previously that although many receptor tyrosine kinase ligands are mitogens for keratinocytes, cell migration and induction of the 92-kilodalton gelatinase/matrix metalloproteinase (MMP)-9 are selectively regulated by the epidermal growth factor and scatter factor/hepatocyte growth factor receptors