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HGF — PRKAG1

Text-mined interactions from Literome

Martínez-Chantar et al., Gastroenterology 2006 : We show here that HGF and 5-aminoimidazole-4-carboxamide-riboside ( AICAR ), an activator of AMP activated protein kinase (AMPK), induce the phosphorylation of AMPK in hepatocytes and that SAM blocks this process
Vázquez-Chantada et al., Hepatology 2009 : Because AMPK is activated by the tumor suppressor kinase LKB1, and AMPK activates endothelial nitric oxide ( NO ) synthase ( eNOS ), and NO synthesis is of great importance for hepatocyte proliferation, we hypothesized that in hepatocytes HGF may induce the phosphorylation of LKB1, AMPK , and eNOS through a process regulated by SAMe, and that this cascade might be crucial for hepatocyte growth