Weiske et al., J Cell Sci 2005
:
In this context, Hint1/PKCI acts as a negative regulator of TCF-beta-catenin transcriptional activity in Wnt transfected cells and in SW480 colon carcinoma cells as shown in reporter gene assays
Wang et al., Cancer Res 2007
(Colonic Neoplasms) :
Because of the important role of the activator protein-1 (AP-1) transcription factor in cancer cells, we examined possible effects of HINT1 on AP-1 transcription factor activity in SW480 cells transfected with an AP-1-luciferase reporter
Wang et al., Int J Cancer 2009
(Carcinoma, Hepatocellular...) :
HINT1 also inhibited NFkappaB transcription factor reporter activity and inhibited translocation of the endogenous p65 protein to the nucleus of HepG2 cells