Gene interactions and pathways from curated databases and text-mining

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HLA-DRB1 — JUN

Text-mined interactions from Literome

Guan et al., Oncogene 2002 : These results indicate that AP-1 regulates DR4 expression via the AP-1 binding site located at -350/-344
Yue et al., Cancer Biol Ther 2006 (Carcinoma, Non-Small-Cell Lung...) : We previously demonstrated that CDDO-Me induces a c-Jun N-terminal kinase (JNK) mediated DR5 expression and apoptosis
Zou et al., Cancer Biol Ther 2007 (Carcinoma, Non-Small-Cell Lung...) : In an effort to understand the mechanism by which CDDO-Me induces apoptosis, particularly in human lung cancer cells, we previously demonstrated that CDDO-Me induces apoptosis involving c-Jun N-terminal kinase (JNK) dependent upregulation of death receptor 5 (DR5) expression
Hwang et al., Amino Acids 2012 (Adenocarcinoma...) : AW00179 potentiates TRAIL mediated death of human lung cancer H1299 cells through ROS-JNK-c-Jun mediated up-regulation of DR5 and down-regulation of anti-apoptotic molecules ... AW00179 also induced the activation of c-Jun and ERK ; however, a pharmacologic inhibition study revealed that JNK-c-Jun signaling is involved in the induction of DR5 expression ... In conclusion, AW00179 has the potential to sensitize H1299 cells to TRAIL mediated apoptosis through two distinct mechanisms : ROS-JNK-c-Jun mediated up-regulation of DR5 , and down-regulation of anti-apoptotic molecules
Cheng et al., Cell cycle (Georgetown, Tex.) 2012 (Neoplasms) : Induction of DR4 and DR5 was independent of p53, Bax and Bim but was dependent on c-Jun N terminal kinase (JNK) as JNK pharmacological inhibition and siRNA abolished the induction of the TRAIL receptors by MMC
Portanova et al., Int J Oncol 2013 : Notch inhibition restores TRAIL mediated apoptosis via AP1 dependent upregulation of DR4 and DR5 TRAIL receptors in MDA-MB-231 breast cancer cells