Gene interactions and pathways from curated databases and text-mining

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CASP12 — HMGCR

Text-mined interactions from Literome

Kuijk et al., Blood 2008 (Mevalonate Kinase Deficiency) : HMG-CoA reductase inhibition induces IL-1beta release through Rac1/PI3K/PKB dependent caspase-1 activation
Liao et al., J Leukoc Biol 2013 : HMG-CoA reductase inhibitors activate caspase-1 in human monocytes depending on ATP release and P2X7 activation