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HMGCR — NOX4

Text-mined interactions from Literome

Tsubouchi et al., Free Radic Biol Med 2005 (Diabetes Mellitus, Experimental) : Here we show that 3-hydroxy-3-methylglutaryl CoA reductase inhibitor ( statin ) attenuates a high glucose induced and a diabetes induced oxidative stress through inhibition of vascular NAD ( P ) H oxidase
Nakagami et al., Curr Diabetes Rev 2005 (Atherosclerosis...) : From the viewpoint of these molecular mechanisms, HMG-CoA reductase inhibitors ( statins ) might inhibit the high glucose induced NADPH oxidase activation through inhibition of Rac activity and finally prevent the increase in ROS production in diabetes
Schramm et al., Vascul Pharmacol 2012 (Cardiovascular Diseases) : Indeed, HMG-CoA reductase inhibitors ( statins ) as well as drugs interfering with the renin-angiotensin-aldosterone system inhibit NADPH oxidase activation and expression