◀ Back to TP53

HOXA5 — TP53

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: TP53 → HOXA5 (increases, TP53 Activity) Raman et al., J Biol Chem 2000*
  Evidence: Recently, we have shown that HOXA5 is a potent transactivator of p53 in breast cells and thus may affect the response of breast cancer cells to DNA damage.

Text-mined interactions from Literome

Raman et al., Nature 2000 (Breast Neoplasms) : Transient transfection of Hox/HOXA5 activated the p53 promoter ... We conclude that loss of expression of p53 in human breast cancer may be primarily due to lack of expression of HOXA5
Gaur et al., Cardiovasc Toxicol 2001 : HoxA5 , a positive regulator of p53 , may be involved with the apoptotic pathway in heart remodeling during amphibian metamorphosis
Chu et al., Cancer Biol Ther 2004 (Breast Neoplasms...) : The mechanism by which estrogen and other estrogen receptor modulators influence both normal breast development as well as breast cancer may involve the regulation of developmental control genes such as HOXA10 ; HOXA10 in turn regulates expression of key downstream genes such as p53 and regulates tumor cell functional phenotype
Gendronneau et al., Am J Pathol 2010 (Carcinoma...) : However, the collaborative nature of this interaction did not depend on the transcriptional regulation of p53 by Hoxa5