Gene interactions and pathways from curated databases and text-mining

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HPD — TNF

Text-mined interactions from Literome

Ranjbar et al., J Immunol 2004 (Tuberculosis, Pulmonary) : Furthermore, these donors displayed a significant increase in CD8 ( + ) T cells and IL-10 levels and lower levels of IL-2 and TNF-alpha relative to PPD-responsive donors in response to PPD stimulation
Yamamoto et al., Tuberculosis (Edinb) 2007 (Tuberculosis, Pulmonary) : Before virulent challenge, BCG vaccination clearly enhanced the ability of BALC, PC and SPC to produce TNF-alpha in response to PPD stimulation ex vivo
Wagner et al., Med Microbiol Immunol 2013 : PPD and LPS significantly increased IL-6, IL-10, and TNF-a production in PBMCs. IL-10 and TNF-a production were significantly lower in a subgroup of CD patients ( 5/12 ) with a known NOD2 mutation
Kato et al., Gan To Kagaku Ryoho 1987 (Carcinoma, Renal Cell...) : In the present study, we achieved a partial response of a metastatic lesion in a patient with renal cancer by the induction of endogenous TNF by PPD and OK-432 ( a streptococcal preparation )
Link et al., J Neuroimmunol 1995 (Inflammation...) : Femtogram concentrations of rTGF-beta 1 suppressed MBP-, PLP- and PPD induced upregulation of IFN-gamma, IL-4, IL-6, tumor necrosis factor-alpha (TNF-alpha) , TNF-beta and perforin in MS, and acetylcholine receptor ( AChR ) -induced augmentation of these pro-inflammatory cytokines in MG, but had no effects on autoantigen- or PPD induced expression of IL-10 or TGF-beta itself
Kowalczyk et al., Immunol Lett 1995 : PPD and rTNF when added singly induced TNF-mRNA accumulation in monocytes
Zembala et al., Cancer Immunol Immunother 1993 (Neoplasms...) : PPD induced TNF production was much weaker and was not significantly changed during this observation time
Lien et al., Blood 1998 (Disease Progression...) : Furthermore, MAC-PPD induced tumor necrosis factor (TNF) release from monocytes through interactions with CD14 and, importantly, the addition of sCD14 enhanced this MAC-PPD stimulatory effect