◀ Back to CCR5

CCR5 — HSPG2

Text-mined interactions from Literome

Fantuzzi et al., Blood 2008 (HIV Infections) : Using a combination of pharmacologic inhibition, confocal laser-scanner microscopy, and enzymatic activity assay, we demonstrate that R5 gp120 interaction with CCR5 activates PC-PLC , as assessed by a time dependent modification of its subcellular distribution and a concentration dependent increase of its enzymatic activity ... Notably, PC-PLC activation through CCR5 is specifically induced by gp120, since triggering CCR5 through its natural ligand CCL4 ( MIP-1beta ) does not affect PC-PLC cellular distribution and enzymatic activity, as well as CCL2 secretion, thus suggesting that different signaling pathways can be activated through CCR5 interaction with HIV-1 or chemokine ligands
Spadaro et al., PloS one 2013 : PI-PLC ß1 activation through CCR5 is also triggered by the natural chemokine ligand CCL4, but independently of ERK1/2