Gene interactions and pathways from curated databases and text-mining

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BMP5 — IFI27

Text-mined interactions from Literome

Sharov et al., Proc Natl Acad Sci U S A 2006 : Primary epidermal keratinocytes ( KC ) from TG mice exhibit significantly increased proliferation and decreased p27 ( Kip1 ) expression, compared with WT KC. Alternatively, activation of BMP signaling in HaCaT KC induces growth arrest, stimulates p27 ( Kip1 ) expression, and positively regulates p27 ( Kip1 ) promoter activity, thus further supporting a role of p27 ( Kip1 ) in mediating the effects of BMP signaling on HF size
Komatsu et al., Development 2011 : The observed defects in cilium development were rescued by the introduction of p27 ( Kip1 ) into Acvr1-deficient MEFs, implying that BMP signaling positively controls p27 ( Kip1 ) stability in the G0 phase via p27 ( Kip1 ) Ser ( 10 ) phosphorylation, which is a prerequisite for induction of primary cilia