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AKT2 — IFNG

Text-mined interactions from Literome

Nguyen et al., J Biol Chem 2001 : IFN gamma activates PI3K as well as Akt in a variety of cell lines
Navarro et al., J Leukoc Biol 2003 : In this study, we demonstrate that IFN-beta or IFN-gamma induces the phosphorylation of the serine/threonine kinase Akt in primary human peripheral blood monocytes
Sakamoto et al., J Leukoc Biol 2005 : Stimulation of neutrophils with IFN-alpha or IFN-gamma resulted in tyrosine phosphorylation of STAT1 and STAT3 but not phosphorylation of STAT5, Akt , extracellular signal regulated kinase, and p38 mitogen activated protein kinase
Venkatesan et al., Cell Signal 2006 : IFN-gamma increased Akt kinase activity in a PI 3 kinase dependent manner ... IFN-gamma had no effect on this complex formation, but did increase PKCepsilon associated Akt kinase activity
Boulday et al., J Immunol 2006 : Moreover, we show that VEGF and IFN-gamma regulate the activation of the IP-10 promoter, and that the kinases PI3K, phosphoinositide dependent kinase 1, and Akt act as intermediary signaling molecules for cytokine-inducible IP-10 transcriptional activation in endothelial cells
Rosner et al., Am J Pathol 2006 (Atherosclerosis) : Interferon-gamma induces Fas trafficking and sensitization to apoptosis in vascular smooth muscle cells via a PI3K- and Akt dependent mechanism ... IFN-gamma also stimulated Akt activity, and both Fas trafficking and Stat1 activation were inhibited by blocking PI3K, Akt, or Jak-2
Hwang et al., Int J Hematol 2006 : IFN-gamma did not enhance SDF-1 induced activation of PI3K/Akt or up-regulate the expression of CXCR4 or its function in bone marrow CD34+ cells
Harvey et al., Arterioscler Thromb Vasc Biol 2007 (Atherosclerosis) : These studies provide novel insights into the role of PI3K/AKT and CK2 in IFN-gamma signaling relevant to changes in macrophage gene expression during atherosclerosis
Boisvert et al., Mol Immunol 2007 : Inhibition studies indicated that activation of ERK and JNK MAPKs and PI3K/AKT are necessary for both TCR- and TCR+alpha2 beta1 integrin dependent IFN-gamma production and that Coll I increases TCR dependent activation of ERK and JNK MAPKs, and AKT
Liu et al., Ann Hematol 2007 (Anemia, Aplastic) : IFN-gamma attenuated Akt phosphorylated by G-CSF in a dose- and time dependent manner
Li et al., Crit Care 2008 (Acute Lung Injury...) : High-tidal-volume ventilation induced type I and type III procollagen mRNA expression, microvascular permeability, hydroxyproline content, Masson 's trichrome staining, S100A4/fibroblast specific protein-1 staining, activation of Akt and extracellular signal regulated kinase ( ERK ) 1/2, and production of macrophage inflammatory protein-2 and 10 kDa IFNgamma-inducible protein in a dose dependent manner
Peairs et al., Clin Exp Immunol 2009 (Lupus Nephritis) : Mechanistically, AICAR inhibited the LPS/IFN-gamma stimulated PI3K/Akt signalling inflammatory cascade but did not affect LPS/IFN-gamma mediated inhibitory kappa B phosphorylation or nuclear factor (NF)-kappaB ( p65 ) nuclear translocation ... Taken together, these observations suggest that AICAR inhibits LPS/IFN-gamma induced Akt phosphorylation through AMPK activation and may serve as a potential therapeutic target in inflammatory diseases
Okubo et al., Mol Nutr Food Res 2010 : Phenethyl isothiocyanate suppresses nitric oxide production via inhibition of phosphoinositide 3-kinase/Akt induced IFN-gamma secretion in LPS activated peritoneal macrophages