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IGFBP3 — STAT1

Text-mined interactions from Literome

Spagnoli et al., J Biol Chem 2002 : Consistent with the up-regulation of STAT-1 mRNA, IGFBP-3 also increased STAT-1 protein expression ... Furthermore, both IGFBP-3 and the IGFBP-3 mutant induced STAT-1 phosphorylation and its nuclear localization
O'Rear et al., J Mol Endocrinol 2005 : We previously reported that IGFBP-3 has IGF independent antiproliferative and apoptotic effects in MCCs, and requires STAT-1 activation to mediate its apoptotic effect ... Furthermore, TGF-beta inhibited STAT-1 phosphorylation induced by IGFBP-3 ... Furthermore, UO126 blocked the TGF-beta inhibition of STAT-1 phosphorylation induced by IGFBP-3 ... Collectively, these results demonstrate cross-talk between the IGFBP-3 dependent STAT-1 signaling and the TGF-beta dependent ERK pathway that regulates MCC proliferation
Fang et al., Growth Horm IGF Res 2008 (Prostatic Neoplasms) : Further analyses revealed that IGFBP-3 , but not IGFBP-1, could significantly enhance the weak tyrosine phosphorylation of STAT1 induced by IFN-gamma ( 20 U/ml ) alone