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IGFBP5 — INS

Text-mined interactions from Literome

Hodgson et al., Regul Pept 2000 : Insulin-like growth factor binding proteins ( IGFBP ) can inhibit or accentuate the mitogenic activities of insulin-like growth factor 1 (IGF-1) depending upon the experimental model employed
Dahlfors et al., Endocrinology 2000 : IGF-I, insulin , or angiotensin II did not affect IGF-I or IGFBP mRNA expression
Chamberlain et al., Mol Cell Endocrinol 2001 : In Experiment 2A, insulin stimulated production of IGFBP-5 by thecal cells, and basic fibroblast growth factor (bFGF) inhibited the insulin induced increase in IGFBP-5 production ; epidermal growth factor (EGF) and luteinizing hormone were without effect ... Production of IGFBP-2/-5 by granulosa cells in Experiment 2B was inhibited by insulin , with EGF and bFGF further enhancing insulin 's inhibitory effect ; follicle stimulating hormone was without effect ... In Experiment 3A, insulin enhanced production of IGFBP-5 by thecal cells whereas glucagon blocked insulin 's stimulatory effect
Mesotten et al., J Clin Endocrinol Metab 2002 (Chronic Disease...) : In the liver, IGFBP-1 is transcriptionally repressed by insulin , and it is therefore a potential marker of hepatic insulin sensitivity
Hsu et al., J Biol Chem 1992 : Unlike cell associated IGFBP-30K, secretion of IGFBP was stimulated ( 6.8 +/- 0.5-fold, n = 2 ) by IGF-I, whereas IGFBP secretion was inhibited 54 % by insulin
Grimes et al., Endocrinology 1992 : IGF-I, IGF-II, and the IGF-I analogs, but not insulin , also induced production of an unidentified 30-kDa IGFBP not normally detectable in these cultures ... However, in the presence of epidermal growth factor ( which was without independent effect on the 30-kDa IGFBP ), insulin also induced this 30-kDa IGFBP
Giudice et al., J Clin Endocrinol Metab 1992 : Since insulin-like growth factors (IGFs) and IGF binding proteins ( IGFBPs ) are believed to be involved in endometrial differentiation, and insulin regulates IGFBP production in a variety of cells, we have investigated the modulatory roles of EGF, progesterone, and insulin on IGFBP secretion by long term cultures of human endometrial stromal cells ... In the nondecidualized state, insulin increased the secretion of IGFBP-3, IGFBP-2 , and the 24-kDa IGFBP, which were slightly inhibited by EGF and relatively unaffected by progesterone alone
Hwang et al., Growth Horm IGF Res 2003 (Carcinoma, Hepatocellular...) : In normal physiology, IGFBP-1 transcription is potently inhibited by insulin and serum levels are limited by a rapid clearance rate
Kiepe et al., Endocrinology 2005 : Insulin-like growth factor (IGF)-I stimulates cell proliferation and induces IGF binding protein (IGFBP)-3 and IGFBP-5 gene expression in cultured growth plate chondrocytes via distinct signaling pathways
Thraikill et al., J Clin Invest 1990 : Cultured human decidual cells release three IGF-BPs with 24,000, 30,000, and 34,000 Mr. Using ligand blot analysis and an RIA for the 30,000-Mr form ( IGF-BP-1 ), we examined the effects of IGF-I ( 10-1,000 ng/ml ), insulin ( 10-10,000 ng/ml ), and relaxin ( 10-250 ng/ml ) on decidual cell IGF-BP release after 120 h of hormone exposure
Zhang et al., Biochem Biophys Res Commun 2007 (Diabetes Mellitus, Type 2) : In contrast, IGFBP-1 augmented glucose stimulated insulin secretion in intact islets, associated with a reduced somatostatin secretion
Martin et al., Endocrinology 1990 (Cell Transformation, Neoplastic) : Insulin tested at 1 microgram/ml did not induce 29-31 K IGFBP
Sureshbabu et al., J Cell Sci 2012 (Breast Neoplasms) : This involves the release of insulin-like growth factor (IGF) binding protein 5 ( IGFBP5 ) from apoptotic cells, which increases the adhesion of epithelial cells on mesenchymal but not epithelial extracellular matrix ( ECM ), and involves the direct interaction of IGFBP5 and a2ß1 integrins
Fang et al., Mol Biol Rep 2012 : Insulin also up-regulated the expression of GHR, IR, IGFBP3 , and IGFBP4 mRNAs, and tended to prevent the transcript levels of IGF-I and IGFBP4 improved by ALA
Pekonen et al., Fertil Steril 1989 (Obesity...) : The authors evaluated the role of insulin in the regulation of serum levels of 34K IGF-BP in patients with polycystic ovarian disease ( PCOD )
Irwin et al., Regul Pept 1993 : We have investigated the regulation by insulin , IGF-I, and IGF-II, of IGFBP secretion in human endometrial stromal cells decidualized in vitro, and examined the interrelationship between the induced changes in IGFBP levels and the biological responses of stromal cells to IGFs
Fielder et al., Growth Regul 1993 : Insulin-like growth factors (IGFs) stimulate and dexamethasone inhibits IGF binding protein (BP)-5 expression in a mouse pituitary cell line
Backeljauw et al., Endocrinology 1993 : Conditioned media IGFBP-5 increased in response to IGF-I, IGF-II, and insulin in a dose dependent fashion, compared with unstimulated FRTL-5 cells ... Stimulation of IGFBP-5 synthesis by the IGFs and insulin appeared to be regulated at the messenger RNA ( mRNA ) level, because each stimulated similar increases in both IGFBP-5 mRNA and media protein at maximally effective concentrations
McFarland et al., Gen Comp Endocrinol 1993 : Equimolar levels of IGF-I or insulin stimulated IGFBP release, however, at levels lower than that induced by IGF-II
Lee et al., Proc Soc Exp Biol Med 1993 : Furthermore, IGFBP-1 regulation by insulin and glucoregulatory hormones in vitro and limited in vivo data are consistent with a role for IGFBP-1 in glucose counterregulation
Duan et al., J Biol Chem 1996 : IGF-II and insulin also increase IGFBP-5 mRNA levels at high doses
McCusker et al., J Cell Physiol 1998 : IGFBP-5 secretion by BC3H-1 cells was increased by either insulin or IGF-I ... IGFBP secretion by L6 cells is stimulated by both insulin/IGF-I and cAMP dependent pathways, whereas IGFBP-5 secretion by BC3H-1 cells is stimulated only by the insulin/IGF pathway