Gene interactions and pathways from curated databases and text-mining

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IKBKE — NFKB1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Shimada et al., Int Immunol 1999 (Inflammation) : Overexpression of wild-type IKK-i phosphorylated serine residues Ser32 and Ser36 of IkappaB-alpha ( preferentially Ser36 ), and significantly stimulated NF-kappaB activation
Nomura et al., Genes Cells 2000 : IKK-i significantly induced NF-kappaB activation upon over-expression, as did IKK-alpha and IKK-beta ... NF-kappaB activation by IKK-i is significantly blocked by coexpression of the N-terminal domain of I-TRAF, dominant negative TRAF2, and dominant negative NIK and IKK-beta ... NF-kappaB activation by IKK-i may be mediated through phosphorylation of I-TRAF by IKK-i and subsequent liberation of TRAF2 ... These results indicate that NF-kappaB activation by IKK-i is mediated through phosphorylation of I-TRAF/TANK by IKK-i and subsequent liberation of TRAF2
Wang et al., FEBS Lett 2004 : A20 also inhibited TRIF-, but not its downstream signaling components TBK1-, IKKbeta-, and IKKepsilon mediated activation of ISRE and NF-kappaB and IFN-beta promoter
Sankar et al., Cell Signal 2006 : Our data suggest that expression of IKK-i can activate both NFkappaB and IRF3, leading to the production of several cytokines including interferon beta
Eddy et al., Cancer Res 2005 (Breast Neoplasms) : Expression of a kinase-inactive IKK-i/IKKepsilon mutant in breast cancer cells reduced NF-kappaB activity as judged by transfection assays of reporters driven either by NF-kappaB elements or the promoters of two NF-kappaB target genes, cyclin D1 and relB
Adli et al., J Biol Chem 2006 (Inflammation) : Here, we demonstrate that IKK-i/IKKepsilon is expressed in a number of cancer cells and is involved in regulating NF-kappaB activity through its ability to control basal/constitutive, but not cytokine induced, p65/RelA phosphorylation at Ser-536, a modification proposed to contribute to the transactivation function of NF-kappaB