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AHSA1 — IL10

Text-mined interactions from Literome

Song et al., J Surg Res 2000 (Bacterial Infections) : The results indicate that p38 MAPK inhibition with SB203580 suppressed the sepsis induced augmentation of interleukin-10 release while restoring the suppressed Th1 cytokine interleukin-2 release typically encountered following sepsis
Song et al., Am J Physiol Cell Physiol 2001 (Infection) : Inhibition of MAPK p38 suppressed in vitro IL-10 levels as well as IL-10 and IL-4 gene expression while restoring the release of IL-2
Salmon et al., Eur J Immunol 2001 : These results indicate first, that p38 MAP kinase activity is required for the production of IL-10 , as well as that of proinflammatory cytokines such as IL-12 and IFN-gamma, and, second, that the net effects of SB 203580 on the production of IL-12 and IFN-gamma can be positive or negative, depending on stimuli, cell populations, and levels of cytokines such as IFN-gamma and IL-10
Guo et al., J Biol Chem 2003 (Inflammation) : Here we show unequivocally that the production of interleukin (IL)-1beta, IL-6, IL-10 , and tumor necrosis factor alpha (TNFalpha) requires p38 MAPK activity by demonstrating that the inhibitory effects of SB 203580 were reversed by expression of an SB 203580-resistant form of p38alpha ( SBR-p38alpha ) that fails to bind to SB 203580
Lucas et al., J Immunol 2005 : The inhibition of either ERK or p38 prevented IL-10 induction, indicating that both MAPKs were required for IL-10 synthesis
Rajasingh et al., FASEB J 2006 (Carotid Artery Injuries) : IL-10 sensitivity to TNF depends on the ability of IL-10 to inhibit the expression and mRNA stabilizing protein HuR and via IL-10 mediated repression of p38 mitogen activated protein ( MAP ) kinase activation
Strle et al., Am J Physiol Endocrinol Metab 2008 (MAP Kinase Signaling System) : IL-10 blocks IL-1beta induced phosphorylation of JNK, but not ERK1/2 or p38 , indicating that only the JNK component of the IL-1beta induced MAPK signaling pathway is targeted by IL-10
Jarnicki et al., J Immunol 2008 (MAP Kinase Signaling System...) : Inhibition of p38 suppressed TLR induced IL-10 and PGE ( 2 ) and enhanced IL-12 production in DC
Krishnamurthy et al., Circ Res 2009 (Disease Models, Animal...) : These changes were associated with IL-10 mediated inhibition of p38 mitogen activated protein kinase activation and repression of the cytokine mRNA stabilizing protein HuR
Goldsmith et al., Mol Immunol 2009 : Our results thus indicate that IL-10 induction by LPS critically depends on basal cAMP level, and that a co-stimulus by a TLR agonist and a cAMP elevating agent results in synergistic PKA dependent and p38 dependent IL-10 production