◀ Back to PIK3CA

IL12A — PIK3CA

Text-mined interactions from Literome

Fukao et al., Nat Immunol 2002 : PI3K mediated negative feedback regulation of IL-12 production in DCs
Williams et al., J Immunol 2004 (Disease Susceptibility...) : Inhibition of PI3K resulted in increased serum levels of IL1-beta, IL-2, IL-6, IL-10, IL-12 , and TNF-alpha in septic mice
Waggoner et al., J Immunol 2005 : Suppression of IL-12 did not result from increased IL-10 or TGF-beta, but was dependent on PI3K activation
Yang et al., Clin Exp Immunol 2006 (MAP Kinase Signaling System...) : The enhancement of IL-12 levels by inhibition of PI 3-K and ERK 1/2 was not reversed by neutralization of TNF-alpha or addition of rhTNF-alpha, suggesting that the negative regulation of IL-12 is not mediated by concomitant TNF-alpha suppression
Kuo et al., J Immunol 2006 : Our results reveal that class III PI3K specifically regulates CpG oligodeoxynucleotide ( ODN ) -induced cytokine and NO production as well as NF-kappaB activation, whereas class I PI3K regulates both CpG ODN- and LPS induced IL-12 production and NF-kappaB activation
Saegusa et al., Mol Immunol 2007 : The enhancement effect of PI3K inhibitors on IL-12 p70 production almost completely disappeared by the treatment with anti-IL-10 mAb ... These results suggest that PI3K positively and negatively regulates the production of CpG-ODN induced IL-10 and IL-12 p70, respectively, and negatively regulates IL-12 p70 production in macrophages through ERK mediated IL-10 induction
He et al., J Immunol 2006 : Expression of IL-12p40 required activation of the p38 MAPK and PI3K
Lee et al., J Leukoc Biol 2007 : Incubation of p110alpha-deficient THP-1 cells with LPS showed that p110alpha was required for IL-12p40 and IL-6 production, whereas it negatively regulated the production of TNF-alpha and IL-10
Liu et al., J Exp Med 2007 (Toxoplasmosis) : We further show that DGKzeta negatively controls the phosphatidylinositol 3-kinase (PI3K)-Akt pathway and that inhibition of PI3K activity or treatment with PA can restore lipopolysaccharide induced IL-12 production by DGKzeta-deficient Mphi
Usluoglu et al., Eur J Immunol 2007 : Different signal pathways mediate LPS induced expression of IL-12 and involve PI3K , MAPK and the transcription factor NF-kappaB
Utsugi et al., J Immunol 2009 (MAP Kinase Signaling System) : Knockdown of PI3K p110alpha by siRNA reduced LPS induced IL-12 protein production in both cell types
Garcia et al., J Immunol 2009 : In the present study, we demonstrate that IL-12p70 induces IL-10 production from human memory CD4+ T cells via a PI3K dependent signaling mechanism
Wenink et al., J Immunol 2009 : The inhibitory effect of TLR2 on the release of TNF-alpha but not of IL-12p70 was mediated by PI3K
Ishikawa et al., Nihon Arukoru Yakubutsu Igakkai Zasshi 2011 : Alternatively, cytokine signaling studies indicate that IL-12 production by DCs is negatively regulated by PI3K and GSK-3, but positively regulated by p38 MAPK, mTOR, and NF-kappa B
Miyazawa et al., J Biochem 2012 : 2011 ; 149 : 265-274 ) recently indicated that PI3K activated downstream of C5a anaphylatoxin does not affect the induction of IL-12 by TLR, although C5a efficiently inhibits the induction, in macrophages