Gene interactions and pathways from curated databases and text-mining

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CD28 — IL12RB2

Text-mined interactions from Literome

Park et al., Eur J Immunol 2001 : When T cells are stimulated with low doses of anti-CD3 mAb, CD28 costimulation was required for the optimal levels of IL-12 receptor (IL-12R) expression
Reddy et al., Cell Immunol 2005 : Superantigens and anti-CD3+anti-CD28 induced higher expression of both IL-12R on PBTs than PHA-P stimulation
Wu et al., Eur J Immunol 1997 : Anti-CD3 induced expression of IL-12Rbeta1 chain and IL-12 binding by PBMC was augmented by anti-CD28 mAb, indicating that the potentiating effect of anti-CD28 on T cell responses to IL-12 could be mediated , at least in part, by the enhancement of IL-12R expression