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IL13 — IL17A

Text-mined interactions from Literome

Chabaud et al., Arthritis Rheum 1999 (Arthritis, Rheumatoid) : The secretion of IL-17 by synovium was measured in the presence of IL-4, IL-13 , and IL-10
Newcomb et al., J Immunol 2009 : CD4 ( + ) Th17 polarized cells from IL-4 knockout ( KO ) mice also had IL-13 induced inhibition of IL-17A production, but this was not observed in IL-4R KO and STAT6 KO mice ... Collectively, we have shown that Th17 cells express a functional IL-13R and that IL-13 negatively regulates IL-17A and IL-21 production by decreasing retinoic acid-related-gammaT expression and while increasing phosphorylation of STAT6 and GATA3 expression
Park et al., J Immunol 2009 (Asthma...) : This study also showed that the inhibition of IL-17 activity with anti-IL-17 Ab remarkably reduced the increased numbers of inflammatory cells of the airways, airway hyperresponsiveness, and the increased levels of IL-4, IL-5, and IL-13 in bronchoalveolar lavage fluid and OVA-specific IgE in serum
Freches et al., Clinical and vaccine immunology : CVI 2011 (Tuberculosis) : Increased pulmonary tumor necrosis factor alpha, interleukin-6 (IL-6), and IL-17A responses compensate for decreased gamma interferon production in anti-IL-12 autovaccine treated, Mycobacterium bovis BCG vaccinated mice
Newcomb et al., J Allergy Clin Immunol 2011 : IL-13 attenuated IL-17A production, as well as expression of retinoic acid related orphan receptor, runt related transcription factor-1, and interferon regulatory factor 4 in T ( H ) 17-polarized cells
Newcomb et al., J Immunol 2012 (Pneumonia...) : IL-13 regulates Th17 secretion of IL-17A in an IL-10 dependent manner ... We have shown previously that IL-13 inhibits Th17 cell production of IL-17A and IL-21 in vitro ... In this study, we extend our in vitro findings and determine that IL-13 increases IL-10 production from Th17 polarized cells and that IL-13 induced IL-10 production negatively regulates the secretion of IL-17A and IL-21 ... To determine if IL-13 negatively regulates lung IL-17A expression via an IL-10 dependent mechanism in vivo, we used a model of respiratory syncytial virus ( RSV ) strain A2 infection in STAT1 knockout ( KO ) mice that increases lung IL-17A and IL-13 expression, cytokines not produced during RSV infection in wild-type mice ... To test the hypothesis that IL-13 negatively regulates lung IL-17A expression, we created STAT1/IL-13 double KO ( DKO ) mice ... Inhibiting IL-13 may decrease IL-10 production and increase IL-17A production, thus potentiating IL-17A associated diseases
Kang et al., Am J Respir Crit Care Med 2012 (Disease Models, Animal...) : We also highlight interactions between these responses with IL-18 inducing IL-13 via an IL-17A dependent mechanism and the type 1 and type17/type 2 responses counterregulating each another
Higaki et al., Clin Exp Allergy 2012 (Eosinophilia...) : LPS pre-treatment enhanced SEB induced IL-5, IL-13 and IL-17A production in diclofenac treated DNPCs, while addition of PGE ( 2 ) inhibited IL-5, IL-13 and IFN-? production
Bystrom et al., Viruses 2013 (Respiratory Syncytial Virus Infections) : Furthermore, IL-17 enhances IL-13 production which, in turn, promotes the activation of Th2 lymphocytes and excessive mucus production