Gene interactions and pathways from curated databases and text-mining

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CASP12 — IL16

Text-mined interactions from Literome

Ludwiczek et al., Eur Cytokine Netw 2001 : Activation of caspase-3 by interferon alpha causes interleukin-16 secretion but fails to modulate activation induced cell death
Reich et al., J Immunol 2001 (Dermatitis, Atopic) : There was evidence that LLDC use caspase-1 to process IL-16, as inhibition of caspase-1 , but not of caspase-3, partially prevented the release of IL-16 in response to ligation of FcepsilonRI
Gianoukakis et al., Endocrinology 2003 : IL-16 but not RANTES expression was dependent on the activity of caspase-3
Guo et al., Blood 2003 : In the present study we confirm that Fas signaling induces both phenotypic and functional maturation of murine DCs, and we demonstrate that phenotypic maturation is associated with phosphorylation of extracellular signal regulated kinase ( ERK ) 1/2, activation of caspase-1 , and secretion of interleukin-beta ( IL-1beta )
Elssner et al., J Immunol 2004 : In contrast, stimulation with bacterial LPS inhibited caspase-3 activation and significantly inhibited the release of IL-16
Skundric et al., J Autoimmun 2005 (Encephalomyelitis, Autoimmune, Experimental...) : Our data suggest that caspase-3 mediated production of IL-16 by infiltrating CD4+ T cells, contributes to ongoing neuroinflammation by chemoattraction of additional waves of CD4+ T cells
Wang et al., Ann Thorac Surg 2005 (Reperfusion Injury) : Myocardial tissue was then assessed for products of p38 MAPK activation, expression of tumor necrosis factor, interleukin-1beta and interleukin-6, and activation of caspase-1, caspase-3 and caspase-11
Shushanov et al., Bull Exp Biol Med 2010 : Insulin-like growth factor-1 and insulin inhibit caspase-3/7 activation initiated by interleukin-1ß in the rat eye retinal neurons
Liao et al., Inflamm Res 2013 : Lipopolysaccharide/adenosine triphosphate mediated signal transduction in the regulation of NLRP3 protein expression and caspase-1 mediated interleukin-1ß secretion