Gene interactions and pathways from curated databases and text-mining

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CXCL10 — IL17D

Text-mined interactions from Literome

Shimizu et al., J Immunol 2006 (Lung Neoplasms...) : Finally, augmented mRNA expression of IP-10 and monokine induced by IFN-gamma was detected at the s.c. B16F10 + IL-27 tumor site, and antitumor activity of IL-27 was partially inhibited by the administration of anti-IP-10
Shibata et al., J Invest Dermatol 2010 (Psoriasis) : Furthermore, IL-27 alone greatly induced in vitro CXCL9, CXCL10 , and CXCL11 production and tyrosine phosphorylation of signal transducer and activator of transcription 1 in normal human keratinocytes, while it suppressed the tumor necrosis factor-alpha induced production of IL-1alpha and CCL20
Cao et al., Chest 2012 (Pulmonary Disease, Chronic Obstructive...) : IL-27 is elevated in patients with COPD and patients with pulmonary TB and induces human bronchial epithelial cells to produce CXCL10 ... The production of IL-27 is related to the pathogenesis of COPD and PTB, and IL-27 induces the expression of CXCL10 in bronchial epithelial cells through the activation of the PI3K-Akt signaling pathway
Zeitvogel et al., J Biol Chem 2012 (Chronic Disease...) : Overexpression of SOCS3 in keratinocytes significantly diminished this enhanced CXCL10 production in response to IL-27